dc.contributor.author | CREAGH, EMMA | en |
dc.contributor.author | MARTIN, SEAMUS | en |
dc.date.accessioned | 2012-01-23T11:29:01Z | |
dc.date.available | 2012-01-23T11:29:01Z | |
dc.date.issued | 2001 | en |
dc.date.submitted | 2001 | en |
dc.identifier.citation | Bouchier-Hayes L, Conroy H, Egan H, Adrain C, Creagh EM, MacFarlane M, Martin SJ, CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways., The Journal of biological chemistry, 276, 47, 2001, 44069-77 | en |
dc.identifier.issn | 0021-9258 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/61799 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Proteins possessing the caspase recruitment domain (CARD) motif have been implicated in pathways leading to activation of caspases or NF-kappaB in the context of apoptosis or inflammation, respectively. Here we report the identification of a novel protein, CARDINAL, that contains a CARD motif and also exhibits a high degree of homology to the C terminus of DEFCAP/NAC, a recently described member of the Apaf-1/Nod-1 family. In contrast with the majority of CARD proteins described to date, CARDINAL failed to promote apoptosis or NF-kappaB activation. Rather, CARDINAL potently suppressed NF-kappaB activation associated with overexpression of TRAIL-R1, TRAIL-R2, RIP, RICK, Bcl10, and TRADD, or through ligand-induced stimulation of the interleukin-1 or tumor necrosis factor receptors. Co-immunoprecipitation experiments revealed that CARDINAL interacts with the regulatory subunit of the IkappaB kinase (IKK) complex, IKKgamma (NEMO), providing a molecular basis for CARDINAL function. Thus, CARDINAL is a novel regulator of NF-kappaB activation in the context of pro-inflammatory signals. | en |
dc.format.extent | 44069-77 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | The Journal of biological chemistry | en |
dc.relation.ispartofseries | 276 | en |
dc.relation.ispartofseries | 47 | en |
dc.rights | Y | en |
dc.subject | Biochemistry | en |
dc.subject | caspase recruitment domain (CARD) | en |
dc.title | CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways. | en |
dc.type | Journal Article | en |
dc.contributor.sponsor | European Union (EU) | en |
dc.contributor.sponsor | Wellcome Trust | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/martinsj | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/ecreagh | en |
dc.identifier.rssinternalid | 77298 | en |
dc.identifier.doi | http://dx.doi.org/10.1074/jbc.M107373200 | en |
dc.relation.ecprojectid | info:eu-repo/grantAgreement/EC/FP7/1999-00739 | |
dc.contributor.sponsorGrantNumber | 1999-00739 | en |
dc.contributor.sponsorGrantNumber | 047580 | en |
dc.subject.TCDTheme | Genes & Society | en |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |