Lead identification of beta-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90
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2011Citation:
O'Boyle, N.M., Knox, A.J.S., Price, T.P., Williams, D.C., Zisterer, D.M., Lloyd, D.G., Meegan, M.J.,, Lead identification of beta-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90, Bioorganic & Medicinal Chemistry, 19, 20, 2011, 6055-6068Download Item:
Abstract:
Heat shock protein 90 is an emerging target for oncology therapeutics. Inhibitors of this molecular chaperone, which is responsible for the maintenance of a number of oncogenic proteins, have shown promise in clinical trials and represent a new and exciting area in the treatment of cancer. Heat shock protein 90 inhibitors have huge structural diversity, and here we present the lead identification of novel inhibitors based on ?-lactam and imine templates. ?-Lactam 5 and imines 12 and 18 exhibit binding to heat shock protein 90-? with IC50 values of 5.6 ?M, 14.5 ?M and 22.1 ?M respectively. The binding affinity displayed by these compounds positions them as lead compounds for the design of future inhibitors of heat shock protein 90 based on the ?-lactam and imine templates.
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Enterprise Ireland
Health Research Board
Science Foundation Ireland
Higher Education Authority
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http://people.tcd.ie/lloyddghttp://people.tcd.ie/mmeegan
http://people.tcd.ie/dzistrer
http://people.tcd.ie/dwillims
http://people.tcd.ie/aknox
http://people.tcd.ie/nioboyle
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Author: MEEGAN, MARY JANE; ZISTERER, DANIELA MARIA; WILLIAMS, DAVID CLIVE; KNOX, ANDREW; LLOYD, DAVID G; O'BOYLE, NIAMH
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Bioorganic & Medicinal Chemistry;19;
20;
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Biochemistry, Oncology, heat shock protein 90Metadata
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