Browsing by Subject "Oncology"
Now showing items 1-20 of 38
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Androgen receptor signaling in prostate cancer development and progression
(Carcinogenesis Press, 2011)The androgen receptor (AR) signaling axis plays a critical role in the development, function and homeostasis of the prostate. The classical action of AR is to regulate gene transcriptional processes via AR nuclear ... -
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.
(2010)Although B-Raf(V600E) is the most common somatic mutation in papillary thyroid carcinoma (PTC), how it induces tumor aggressiveness is not fully understood. Using gene set enrichment analysis and in vitro and in vivo ... -
Cancer Cachexia:Mechanisms and Clinical Implications
(Hindawi, 2011)Cachexia is amultifactorial process of skeletal muscle and adipose tissue atrophy resulting in progressive weight loss. It is associated with poor quality of life, poor physical function, and poor prognosis in cancer ... -
Characterisation and manipulation of docetaxel resistant prostate cancer cell lines
(2011)Background: There is no effective treatment strategy for advanced castration-resistant prostate cancer. Although Docetaxel (Taxotere?) represents the most active chemotherapeutic agent it only gives a modest survival ... -
Correlation of p16(INK4A) expression and HPV copy number with cellular FTIR spectroscopic signatures of cervical cancer cells.
(2011)Cervical cancer, a potentially preventable disease, has its main aetiology in infection by high risk human papillomavirus (HR-HPV). Approaches to improving cervical cancer screening and diagnostic methodologies include ... -
COX-Derived prostanoid pathways in gastrointestinal cancer development and progression: Novel targets for prevention and intervention
(Elsevier, 2012)Arachidonic acid metabolism through cyclooxygenase (COX) pathways leads to the generation of biologically active eicosanoids. Eicosanoid expression levels vary during development and progression of gastrointestinal (GI) ... -
The development and feasibility of the occupational therapy-led `Work and Cancer' intervention for women living with and beyond breast cancer
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2022)Background: Increased survivorship has prompted focus on optimising quality of life for those living with and beyond cancer, including reintegration into work. Despite frequently cited return-to-work barriers for women ... -
Diagnostic accuracy systematic review of rectal bleeding in combination with other symptoms, signs and tests in relation to colorectal cancer
(2010)Background: Rectal bleeding is a recognised early symptom of colorectal cancer. This study aimed to assess the diagnostic accuracy of symptoms, signs and diagnostic tests in patients with rectal bleeding in relation ... -
A double prodrug system for colon targeting of benzenesulfonamide COX-2 inhibitors
(2011)The design, synthesis and delivery potential of a new type of benzenesulfonamide cyclo-oxygenase-2 (COX-2) inhibitor prodrug is investigated using celecoxib. The approach involves a double prodrug that is activated first ... -
Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines.
(Springer, 2010)Advanced hormone-refractory prostate cancer is associated with poor prognosis and limited treatment options. Members of the pyrrolo-1,5-benzoxazepine (PBOX) family of compounds exhibit anti-cancer properties in cancer cell ... -
Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer.
(2009)The identification of biomarkers that distinguish between aggressive and indolent forms of prostate cancer (PCa) is crucial for diagnosis and treatment. In this study, we used cultured cells derived from prostate tissue ... -
Endothelin inhibitors for advanced prostate cancer
(John Wiley, 2011)This is the protocol for a review and there is no abstract. The objectives are as follows: Our review aims to determine the effectiveness and adverse effects of endothelin inhibitors for advanced prostate cancer. The ... -
Epigenetic Regulation of Glucose Transporters in Non-Small Cell Lung Cancer
(MDPI, 2011)Due to their inherently hypoxic environment, cancer cells often resort to glycolysis, or the anaerobic breakdown of glucose to form ATP to provide for their energy needs, known as the Warburg effect. At the same time, ... -
Epigenetics Underpinning the Regulation of the CXC (ELR+) Chemokines in Non-Small Cell Lung Cancer
(PLoS, 2011)Background: Angiogenesis may play a role in the pathogenesis of Non-Small Cell Lung cancer (NSCLC). The CXC (ELR+) chemokine family are powerful promoters of the angiogenic response. Methods: The expression of the CXC ... -
Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival.
(2010)BACKGROUND: Overexpression of the fatty acid synthase (FASN) gene has been implicated in prostate carcinogenesis. We sought to directly assess the oncogenic potential of FASN. METHODS: We used immortalized human prostate ... -
Folic acid modified gelatine coated quantum dots as potential reagents for in vitro cancer diagnostics.
(2011)BACKGROUND: Gelatine coating was previously shown to effectively reduce the cytotoxicity of CdTe Quantum Dots (QDs) which was a first step towards utilising them for biomedical applications. To be useful they also need ... -
FOXA1 is a potential oncogene in anaplastic thyroid carcinoma
(2009)Purpose: FOXA1 is a mammalian endodermal transcription factor belonging to the human forkhead box gene family that plays a role in certain tumor types. Here, we investigated the potential role of FOXA1 in human thyroid ... -
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
(2011)Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation ... -
Gleason score and lethal prostate cancer: does 3 + 4 = 4 + 3?
(2009)PURPOSE Gleason grading is an important predictor of prostate cancer (PCa) outcomes. Studies using surrogate PCa end points suggest outcomes for Gleason score (GS) 7 cancers vary according to the predominance of pattern ... -
Head and neck squamous cell carcinoma in the young: a spectrum or a distinct group? Part 1.
(2009)While most head and neck squamous carcinoma (HNSCC) occurs in older people, an increasing number of young patients are being affected worldwide, with up to 5.5% <40. These are predominantly oral and oropharyngeal cancers. ...