Browsing Pharmacology & Therapeutics by Date of Publication
Now showing items 21-40 of 84
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A cluster randomised trial of educational interventions to promote rational prescribing in primary care
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)A randomised controlled trial (RCT) was used to evaluate the effectiveness of individualised GP prescribing feedback delivered as a postal bulletin (PB, n=50 practices) compared to PB plus academic detailing visits (AD, ... -
Left ventricular diastolic function in early hypertension
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)This thesis presents the development of clinical applications of the relatively new ultrasound modality, TDI in conjunction with the earlier more established modalities of echocardiography. The contents of this thesis ... -
Health economics in the Irish healthcare setting
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)Economic analysis plays a key role in deciding which healthcare interventions should be made available in collectively funded healthcare systems. The aim of this thesis is to examine the application of health economics in ... -
Genetic polymorphisms and arterial stiffness
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)Arterial stiffness exerts a major influence on cardiac afterload and coronary perfusion. Indices of arterial stiffness have therefore been proposed as surrogate markers of cardiovascular risk and as potential therapeutic ... -
Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity
(Oxford University Press, 2008)Non-steroidal anti-inflammatory agents (NSAIDs) are associated with a marked reduction in the risk of developing Alzheimer's disease, a form of dementia characterized by the accumulation of amyloid plaques containing the ... -
Prescription refill models of medication taking behaviour
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2009)Medication taking can be defined in terms of two separate and distinct behaviours; adherence and persistence. These behaviours represent the ways in which a patient may take a treatment correctly; namely, acting in accordance ... -
Assessment of arterial stiffness using oscillometric arteriography
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2009)The present series of studies examined whether an oscillometric method (Arteriograph), which measures arterial stiffness indices, pulse wave velocity (PWV m/sec), and wave reflection as augmentation index [Alx %], is on ... -
Remodelling by early-life stress of NMDA receptor-dependent synaptic plasticity in a gene-environment rat model of depression.
(2009)An animal model of depression combining genetic vulnerability and early-life stress (ELS) was prepared by submitting the Flinders Sensitive Line (FSL) rats to a standard paradigm of maternal separation. We analysed hippocampal ... -
GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo
(2010)Currently, treatment with the relatively low-affinity NMDA receptor antagonist memantine provides limited benefit in Alzheimer's disease (AD). One probable dose-limiting factor in the use of memantine is the inhibition of ... -
A competing risks prescription refill model of compliance and persistence.
(2010)Objectives There is evidence to suggest that noncompliant and nonpersistent behaviors have differing risk factors, clinical consequences, and responses to intervention. This has led to calls for these behaviors to be defined ... -
Pharmacoepidemiology of diabetes mellitus in a national population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2010)Diabetes is associated with significant morbidity and mortality from microvascular and macrovascular complications. It is projected that the prevalence of diabetes will increase worldwide especially in the elderly population ... -
Antibodies prevent the acute inhibition of long term potentiation by amyloid beta in the rat hippocampus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2010)The present study investigated the mechanisms underlying the inhibition of long-term potentiation (LTP) of excitatory synaptic transmission by amyloid beta (Aβ) in the anaesthetized rat hippocampus. The role of soluble Aβ ... -
Medicinal plants used by traditional medicine practitioners for the treatment of HIV/AIDS and related conditions in Uganda
(Elsevier, 2010)Introduction and objectives: In Uganda, there are over 1 million people with HIV/AIDS. When advanced, this disease is characterized by life-threatening opportunistic infections. As the formal health sector struggles to ... -
Interaction between prion protein and toxic amyloid ß assemblies can be therapeutically targeted at multiple sites.
(2011)A role for PrP in the toxic effect of oligomeric forms of A?, implicated in Alzheimer's disease (AD), has been suggested but remains controversial. Here we show that PrP is required for the plasticity-impairing effects of ... -
Antimicrobial management and appropriateness of treatment of urinary tract infection in general practice in Ireland.
(2011)BACKGROUND: Urinary tract infections (UTIs) are the second most common bacterial infections in general practice and a frequent indication for prescription of antimicrobials. Increasing concern about the association between ... -
Pharmacokinetics of selected antiretroviral and antimalarial drugs in Ugandan adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2011)Human immunodeficiency virus (HIV) and malaria are two major infectious diseases causing significant morbidity and mortality worldwide. The two have overlapping geographical distribution in sub-Saharan Africa, where over ... -
β-adrenoceptor-mediated regulation of matrix metalloproteinase-9 in fibroblasts
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2011)Adrenoceptor signalling in fibroblasts: Intracellular cAMP levels were measured by a direct cAMP enzyme immunoassay. Isoprenaline (ISO, 1 μM) increased intracellular cAMP concentration by 1.3 and 4.8 fold, P<0.05, after ... -
Glutamate receptors in preclinical research on Alzheimer's disease: update on recent advances
(2012)The cognitive and related symptoms of Alzheimer's disease are mainly attributable to synaptic failure. Here we review recent research on how the Alzheimer's disease amyloid ?-protein (A?) affects glutamate receptors and ... -
Alzheimer's disease Aß assemblies mediating rapid disruption of synaptic plasticity and memory.
(2012)Alzheimer’s disease (AD) is characterized by episodic memory impairment that often precedes clinical diagnosis by many years. Probing the mechanisms of such impairment may provide much needed means of diagnosis and therapeutic ...