Browsing Genetics (Theses and Dissertations) by Subject "Genetics & Microbiology, Ph.D."
Now showing items 1-18 of 18
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Characterisation of the second binding protein of immunoglobulin (SBi) in Straphylococcus aureus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)The second binding protein for immunoglobulin (Sbi) of Staphylococcus aureus comprises two IgG binding domains (D1 and D2) that share 30% sequence homology with the IgG binding domains of protein A (Spa) and two domains ... -
Dissecting the functional link between transcription factor codes and axon guidance genes in Drosophila motor neurons
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)As axons navigate through the extracellular environment they are exposed to different guidance cues that will steer them when sensed by receptors and cell adhesion molecules [CAMS) present on their membranes. The intricate ... -
Evolution of the OmpR regulon in Salmonella enterica serovar Typhimurium and Escherichia coli in response to low pH
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)Two-component systems (TCS) enable bacteria to sense, respond and adapt to a wide range of environmental stimuli. The OmpR/EnvZ TCS is composed of the inner membrane sensor kinase EnvZ and the response regulator OmpR. In ... -
Expression of hns and stpA in Salmonella enterica servoar Typhimurium
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)H-NS-like proteins are widespread amongst Enterobacteriaceae and other Gramnegative bacteria. They are small (15 kDa) nucleoid associated proteins involved in many cellular processes such as replication, transposition, ... -
From single nucleotide polymorphisms to high-throughput sequencing in the complex genetics of amyotrophic lateral sclerosis
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive weakening of limb and bulbar muscles resulting in paralysis and death from respiratory failure within three to five years ... -
Functional analyses of a novel leucine-rich repeat-containing protein, Elfn1, in the mouse
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)The functional brain is critically dependent on a highly specific and perfectly timed gene-expression programme that underlies neuronal connectivity. Each step of this process, which includes cell migration, axon guidance, ... -
Genetic mechanisms establishing thalamocortical connectivity : novel genes and a role for Semaphorin6B
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)One of the main functions of the brain is to process information from the environment. All input to the neocortex passes through the thalamus in order to be handled. Therefore, proper connectivity between the thalamus and ... -
Identification and characterisation of a novel Polycomb Repressive Complex 2 associated protein that is an alternatively spliced product of the LCOR gene locus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2015)Polycombs are evolutionary conserved epigenetic regulators crucial for specification of cell types during development. They assemble in multiprotein complexes to modify amino terminal tails of histone H3 at lysine 27 to ... -
Investigation of the molecular mechanisms of functional innovation
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)The robustness to perturbations and evolvability of genomes are two major principles that govern the emergence of genetic diversity across all forms of life. Functional innovations that occur through the genetic diversity ... -
Iron regulated surface determinants of Staphylococcus aureus and S. lugdunensis : their roles in pathogen-host interactions
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)Staphylococcus aureus is a human pathogen that causes invasive infections. The ability to internalize into and persist within host cells is thought to contribute to pathogenesis. The study described here has identified a ... -
MicroRNA regulation of the bovine alveolar macrophage response to Mycobacterium bovis
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Bovine tuberculosis is one of the most economically significant infectious diseases of cattle in Ireland and globally, resulting in economic losses of approximately €2 billion annually. The causative agent is Mycobacterium ... -
Next generation sequencing of ancient DNA
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)The application of next generation sequencing (NGS) technologies into the field of ancient DNA has seen a paradime shift in the level of analysis that can be completed using archaeological samples. However, to fully access ... -
Olfactory-avoidance habituation in Drosophila melanogaster
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Habituation is a form of sensory filtering in response to prolonged or repeated stimuli in the environment [Harris, 1943; Thompson and Spencer, 1966; Christoffersen, 1997; Rankin et al., 2009], It provides biological ... -
Rational design of artificial genetic switches : co-option of H-NS-repressed operons by the VirB virulence master regulator
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)The H-NS protein represses the transcription of hundreds of genes in Gram-negative bacteria. De-repression is achieved by a multitude of mechanisms, many of which involve binding of a protein to DNA at the repressed promoter ... -
Staphylococcus lugdunensis : Genome sequence, genetic systems, virulence and an amplifiable isd locus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)Staphylococcus lugdunensis is a coagulase negative staphylococcus (CoNS). Infections caused by CoNS are normally less severe than infections caused by S. aureus. However, S. lugdunensis is associated with a series of severe ... -
Surface proteins and restriction-modification systems of bovine mastitis strains of Staphylococcus aureus
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)Staphylococcus aureus is frequently associated with bovine mastitis, one of the most economically important diseases in the dairy industry. The bovine S. aureus strain RF122 represents a geographically widespread clone ... -
Sustained expression of fis, the gene coding for the Fis nucleoid-associated protein, during the stationary phase of growth in Salmonella enterica
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2013)The Factor for Inversion Stimulation (Fis) is a global regulator of virulence genes in Salmonella enterica serovar Typhimurium. Previously, the Fis protein was throught to be expressed only during the early exponential ... -
The genetics of amyotrophic lateral sclerosis
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)Amyotrophic lateral sclerosis, commonly referred to as motor neuron disease or simply ALS, is a neurological disorder which involves the degeneration of upper and lower motor neurons. The disease is associated with a ...