Browsing Pharmaceutical Chemistry (Theses and Dissertations) by Title
Now showing items 1-20 of 25
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Characterisation and analysis of beta-aminoketones as potential prodrugs for amines
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)The aim of the work described in this thesis is to evaluate the potential of β-aminoketones as amine prodrugs. These compounds are usually stable in acidic conditions while they cleave into the parent amine and an ... -
Design and synthesis of 4-[1,3-diaryl-1H-pyrazole-4-yl]-2,6-dimethyl-1,4-dihydropyridine compounds and evaluation as anti-proliferative and multi-drug resistance reversal agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)1,4-Dihydropyridines are well known for their use as calcium channel blockers and are extensively used in treatment of hypertension. Dihydropyridine derivatives such as nifedipine have been shown to have the potential to ... -
Design and synthesis of novel isoquinoline monoamineoxidase inhibitors
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)The work described in this thesis consists of the synthesis and biological evaluation of a series of reduced isoquinoline derivatives. MAO is an enzyme involved in the metabolic degradation of catecholamine neurotransmitters. ... -
Design, synthesis and biochemical evaluation of dual-acting, estrogen receptor ligand conjugates
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)Selective targeting of malignancies over healthy cells is an important goal in cancer therapies. Knowledge of environmental and biological differences between tumours and healthy tissue can present suitable targets for ... -
Design, synthesis and biochemical evaluation of novel 1,2,3,4-tetrahydroisoquinolines as anti-proliferative agents in breast cancer cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)Isoquinolines are naturally occurring alkaloids that have shown biological activity in a number of different areas. In terms of breast cancer, tetrahydroisoquinoline based compounds have shown potential as selective estrogen ... -
Design, synthesis and biochemical evaluation of novel antiproliferative agents for the treatement of Burkitt's Lymphoma
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)This thesis is concerned with the identification of novel antiproliferative agents for the treatment of Burkitt's lymphoma (BL), an aggressive B-cell malignancy. Numerous SERT and NET ligand such as SSRIs and TCAs, having ... -
Development of the beta-lactam structure as a scaffold for biologically active compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)Tamoxifen is a selective estrogen receptor modulator (SERM) with a triarylethylene structure which acts as an estrogen antagonist in the breast. This drug is used extensively as an endocrine treatment for breast cancer, ... -
Development, validation and optimisation of a vHTS protocol for identification of estrogen receptor modulators
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2006)The discovery of small-molecule drugs has reached a critical point in time where the number of new drugs released to market has become static regardless of the technological advances observed over the last few years. ... -
Dual acting nuclear receptor targeting conjugates : design, synthesis and biochemical evaluation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Breast cancer has become the second most common cancer worldwide after lung cancer, the fifth most common cause of cancer death, and the foremost cause of cancer death in women. Worldwide, breast cancer exceeds all other ... -
Flexible estrogen receptor modulators
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)Tamoxifen is a selective estrogen receptor modulator (SERM) with a triarylethylene structure, which has estrogenic activity in bone and endometrial tissue, yet antagonises the actions of estrogen in other tissues including ... -
Identification of novel targets for cancer chemotherapeutic agents : design, synthesis and evaluation of chromene based compounds with affinity for steroid hormone receptors
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Breast cancer is the second most common cancer in Ireland and accounts for 28% of all cancers in women in Ireland, with an average of 1726 new diagnosis each year. One of the major therapeutic advances in clinical treatment ... -
Investigations of beta-lactams as novel bioactive compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)A natural stilbene product combretastatin A-4 (CA-4) is a known anti-cancer compound, which exerts its mechanism of action at the colchicine binding site on tubulin, a protein that is essential for the replication of cells. ... -
Stability and hydrolysis studies of novel dual acting conjugate drugs with anitcancer activity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)Tamoxifen is currently a first-line endocrine therapy for the adjuvant treatment of Estrogen Receptor (ER) positive breast cancer. The antiestrogenic properties of this compound are related to its ability to compete for ... -
Studies in the design and synthesis of novel selective serotonin reuptake inhibitors
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)The serotonin transporter (SERT) has been the target of several modern day antidepressants with the focus on achieving selectivity over other monoamine transporters, thereby minimising the side effects observed in the older ... -
Studies in the synthesis and impurity profiling of Methylenedioxy and Alkylthioamphetamines
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)3,4-Methylenedioxymethamphetamme (MDMA, Ecstasy) and other, so-called, designer amphetamines, have become popular drugs of abuse over the past number of years. Detailed knowledge of the synthetic methods employed by ... -
Studies in the synthesis and in vitro hydrolysis of novel aspirin prodrugs
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)Prolonged aspirin use has been associated with an increased risk of gastrointestinal bleeding, leading in some instances to haemorrhage and death. This thesis describes the design of aspirin prodrugs, from which aspirin ... -
Studies into the in vitro metabolism and antiplatelet effects of novel aspirin ester prodrugs
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)Aspirin is the most commonly used antiplatelet agent in the world, and is invaluable in prevention o f myocardial infarction, thrombosis and stroke. However prolonged use has been associated with gastrointestinal side-effects ... -
Synthesis of intermediates for carbapenem antibiotics and synthetic analogues of dehydroepiandrosterone (DHEA)
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)The work presented in this thesis is divided into two parts. Part one consists of the synthesis and chemical modification of β-lactams as potential intermediates for carbapenem antibiotics. Part two describes the synthesis ... -
Synthesis, biochemical evaluation and structural studies of novel antiproliferative βeta-lactams
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)The synthesis and antiproliferative evaluation of anti-cancer β-lactams targeting tubulin, heat shock protein 90 and the estrogen receptor is described. Compounds were planned to include relevant substituents known to ... -
Synthetic, photophysical and biological studies into new tools for investigating bile acid disposition and toxicity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The overall objective of this thesis was to use synthetic chemistry to provide tools to understand problems in bile acid research including their disposition and mechanism of toxicity. Fluorescent reporter groups are very ...