Studies into the in vitro metabolism and antiplatelet effects of novel aspirin ester prodrugs
Citation:
Maeve Lally, 'Studies into the in vitro metabolism and antiplatelet effects of novel aspirin ester prodrugs', [thesis], Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003, pp 309Download Item:
Abstract:
Aspirin is the most commonly used antiplatelet agent in the world, and is invaluable in prevention o f myocardial infarction, thrombosis and stroke. However prolonged use has been associated with gastrointestinal side-effects such as ulceration and haemorrhage which may be fatal. This thesis describes the design and evaluation of aspirin prodrugs, which may liberate aspirin only on reaching the circulation, thus circumventing the GIT and having a potentially less severe gastrotoxicity profile.
Author: Lally, Maeve
Advisor:
Gilmer, JohnQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical SciencesNote:
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