Browsing Microbiology (Scholarly Publications) by Sponsor "Science Foundation Ireland (SFI)"
Now showing items 1-20 of 54
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Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
(2014)Staphylococcus aureus is an important opportunistic pathogen and persistently colonizes about 20% of the human population. Its surface is 'decorated' with proteins that are covalently anchored to the cell wall peptidoglycan. ... -
Antimitotic herbicides bind to an unidentifed site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites.
(2013)Malarial parasites are exquisitely susceptible to a number of microtubule inhibitors but most of these compounds also affect human microtubules. Herbicides of the dinitroaniline and phosphorothioamidate classes however ... -
Bacterial DNA topology and infectious disease
(2009)he gram-negative bacterium Escherichia coli and its close relative Salmonella enterica have made important contributions historically to our understanding of how bacteria control DNA supercoiling and of how supercoiling ... -
Bacterial regulon evolution: distinct responses and roles for the identical OmpR proteins of Salmonella Typhimurium and Escherichia coli in the acid stress response
(2014)The evolution of new gene networks is a primary source of genetic innovation that allows bacteria to explore and exploit new niches, including pathogenic interactions with host organisms. For example, the archetypal DNA ... -
Broad scale redistribution of mRNA abundance and transcriptional machinery in response to growth rate in Salmonella enterica serovar Typhimurium
(2017)We have investigated the connection between the four-dimensional architecture of the bacterial nucleoid and the organism's global gene expression programme. By localizing the transcription machinery and the transcriptional ... -
Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus, and decreases complement-mediated phagocytosis
(2010)The human complement system is important in the immunological control of Staphylococcus aureus infection. We showed previously that S. aureus surface protein clumping factor A (ClfA), when expressed in recombinant form, ... -
Clumping factor A of Staphylococcus aureus inhibits phagocytosis by human polymorphonuclear leucocytes
(2006)Staphylococcus aureus is a major cause of nosocomial and community-acquired infection. It expresses several factors that promote avoidance of phagocytosis by polymorphonuclear leucocytes. Clumping factor A (ClfA) is a ... -
Co-operative roles for DNA supercoiling and nucleoid-associated proteins in the regulation of bacterial transcription
(2013)DNA supercoiling and NAPs (nucleoid-associated proteins) contribute to the regulation of transcription of many bacterial genes. The horizontally acquired SPI (Salmonella pathogenicity island) genes respond positively to ... -
Consequences of producing DNA gyrase from a synthetic gyrBA operon in Salmonella enterica serovar Typhimurium
(2021)DNA gyrase is an essential type II topoisomerase that is composed of two subunits, GyrA and GyrB and has an A 2 B 2 structure. Although both subunits are required in equal proportions to form DNA gyrase, the gyrA and gyrB ... -
Control of virulence gene transcription by indirect readout in Vibrio cholerae and Salmonella enterica serovar Typhimurium
(2017)Indirect readout mechanisms of transcription control rely on the recognition of DNA shape by transcription factors (TFs). TFs may also employ a direct readout mechanism that involves the reading of the base sequence in the ... -
Design and evaluation of antimalarial peptides derived from prediction of short linear motifs in proteins related to erythrocyte invasion
(2015)The purpose of this study was to investigate the blood stage of the malaria causing parasite, Plasmodium falciparum, to predict potential protein interactions between the parasite merozoite and the host erythrocyte and ... -
DNA supercoiling and the Lrp protein determine the directionality of fim switch DNA inversion in Escherichia coli K-12
(2006)Site-specific recombinases of the integrase family usually require cofactors to impart directionality in the recombination reactions that they catalyze. The FimB integrase inverts the Escherichia coli fim switch (fimS) in ... -
DNA supercoiling and transcription: a two-way street
(2019)Background : The processes of DNA supercoiling and transcription are interdependent because the movement of a transcription elongation complex simultaneously induces under- and over winding of the DNA duplex and because ... -
The effect of mobile element IS10 on experimental regulatory evolution in Escherichia coli
(2010)Mobile genetic elements are widespread in bacteria, where they cause several kinds of mutations. Although their effects are on the whole negative, rare beneficial mutations caused by insertion sequence elements are frequently ... -
Fermentation innovation through complex hybridization of wild and domesticated yeasts
(2019)The most common fermented beverage, lager beer, is produced by interspecies hybrids of the brewing yeast Saccharomyces cerevisiae and its wild relative S. eubayanus. Lager-brewing yeasts are not the only example of hybrid ... -
Fibrinogen is a ligand for the S. aureus MSCRAMM Bbp (Bone sialoprotein-binding protein).
(2011)MSCRAMMs (microbial surface components recognizing adhesive matrix molecules) are bacterial surface proteins mediating adherence of the microbes to components of the extracellular matrix of the host. On Staphylococci the ... -
Fibronectin-binding protein B variation in Staphylococcus aureus
(2010)Background: Fibronectin binding proteins A and B (FnBPA and FnBPB) mediate adhesion of S.aureus to fibrinogen, elastin and fibronectin. We previously identified seven different isotopes of FnBPA based on divergence in the ... -
A fundamental regulatory mechanism operating through OmpR and DNA topology controls expression of Salmonella pathogenicity islands SPI-1 and SPI-2
(2012)DNA topology has fundamental control over the ability of transcription factors to access their target DNA sites at gene promoters. However, the influence of DNA topology on protein–DNA and protein–protein interactions is ... -
Genome architecture and global transcriptional control in bacteria: making progress towards a unified model?
(2013)Data obtained with advanced imaging techniques, chromosome conformation capture methods, bioinformatics and molecular genetics, together with insights from polymer physics and mechanobiology, are helping to refine our ...