Browsing Biochemistry (Scholarly Publications) by Author "ZISTERER, DANIELA MARIA"
Now showing items 1-5 of 5
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Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines.
LAWLER, MARK; WILLIAMS, DAVID CLIVE; NATHWANI, SEEMA; MEEGAN, MARY JANE; ZISTERER, DANIELA MARIA (Springer, 2010)Advanced hormone-refractory prostate cancer is associated with poor prognosis and limited treatment options. Members of the pyrrolo-1,5-benzoxazepine (PBOX) family of compounds exhibit anti-cancer properties in cancer cell ... -
Lead identification of beta-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90
MEEGAN, MARY JANE; ZISTERER, DANIELA MARIA; WILLIAMS, DAVID CLIVE; KNOX, ANDREW; LLOYD, DAVID G; O'BOYLE, NIAMH (Elsevier, 2011)Heat shock protein 90 is an emerging target for oncology therapeutics. Inhibitors of this molecular chaperone, which is responsible for the maintenance of a number of oncogenic proteins, have shown promise in clinical ... -
Lead identification of conformationally restricted ?-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects
GREENE, LISA; ZISTERER, DANIELA MARIA; MEEGAN, MARY JANE; LLOYD, DAVID G (Elsevier, 2010)The synthesis and study of the structure-activity relationships of a series of rigid analogues of combretastatin A-4 are described which contain the 1,4-diaryl-2-azetidinone (?-lactam) ring system in place of the usual ... -
Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo
ZISTERER, DANIELA MARIA; WILLIAMS, DAVID CLIVE; MC ELLIGOTT, TONY (Nature, 2010)Background: Imatinib is a direct and potent inhibitor of the constitutively active tyrosine kinase, breakpoint cluster region-Abelson (Bcr-Abl), which is central to the pathogenesis of chronic myeloid leukaemia (CML) ... -
Synthesis, Biochemical and Molecular Modelling Studies of Antiproliferative Azetidinones causing Microtubule Disruption and Mitotic Catastrophe
MEEGAN, MARY JANE; ZISTERER, DANIELA MARIA; KEELY, NIALL O.; MC CABE, THOMAS; GREENE, LISA; KNOX, ANDREW; LLOYD, DAVID G; O'BOYLE, NIAMH (Elsevier, 2011)The structure-activity relationships of antiproliferative ?-lactams, focusing on modifications at the 4-position of the ?-lactam ring, is described. Synthesis of this series of compounds was achieved utilizing the Staudinger ...