Browsing Biochemistry (Scholarly Publications) by Author "O'NEILL, LUKE"
Now showing items 1-20 of 55
-
A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling
O'NEILL, LUKE; BOWIE, ANDREW (2000)Poxviruses employ many strategies to evade and neutralize the host immune response. In this study, we have identified two vaccinia virus ORFs, termed A46R and A52R, that share amino acid sequence similarity with the Toll/IL-1 ... -
Both TLR2 and TRIF contribute to interferon-? production during Listeria infection.
O'NEILL, LUKE; CORR, SINEAD (2012)Synthesis of interferon-? (IFN-?) is an innate response to cytoplasmic infection with bacterial pathogens. Our recent studies showed that Listeria monocytogenes limits immune detection and IFN-? synthesis via deacetylation ... -
Bruton's Tyrosine Kinase Mediates the Synergistic Signalling between TLR9 and the B Cell Receptor by Regulating Calcium and Calmodulin
DOYLE, SARAH; O'NEILL, LUKE; QUINN, SUSAN (2013)B cells signal through both the B cell receptor (BCR) which binds antigens and Toll-like receptors (TLRs) including TLR9 which recognises CpG DNA. Activation of TLR9 synergises with BCR signalling when the BCR and TLR9 ... -
Building unique bonds to fight misplaced DNA
O'NEILL, LUKE (2013)A cyclic dinucleotide comprised of GMP and AMP was previously shown to be a key intermediate during activation of innate immune responses to cytosolic DNA. A report by Patel and Tuschl groups published in Cell reveals the ... -
Camelpox virus encodes a schlafen-like protein that affects orthopoxvirus
O'NEILL, LUKE; BRADY, GARETH (2007)Camelpox virus (CMLV) gene 176R encodes a protein with sequence similarity to murine schlafen (m-slfn) proteins. In vivo, short and long members of the m-slfn family inhibited T-cell development, whereas in vitro, only ... -
Cardiolipin and the Nlrp3 inflammasome.
O'NEILL, LUKE (2013)The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin ... -
Circadian Clock Proteins and Immunity
O'NEILL, LUKE; CURTIS, ANNIE (2014)Immune parameters change with time of day and disruption of circadian rhythms has been linked to inflammatory pathologies. A circadian-clock-controlled immune system might allow an organism to anticipate daily changes in ... -
Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1.
CURTIS, ANNIE; O'NEILL, LUKE; HOKAMP, KARSTEN (2015)The circadian clock allows an organism to anticipate daily changes imposed by the environment. The response to LPS is altered depending on time of day; however, the molecular mechanisms underlying this are unclear. We find ... -
Counter-regulation in the IKK family.
O'NEILL, LUKE (2011)The human IKK [I?B (inhibitor of NF-?B) kinase] family has four members; they are the central kinases of innate immunity. Two members, IKK? and IKK?, the so-called canonical members, phosphoryate I?B?, leading to activation ... -
The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes
O'NEILL, LUKE; COLL, REBECCA (2011)BACKGROUND: The Inflammasomes are multi-protein complexes that regulate caspase-1 activation and the production of the pro-inflammatory cytokine IL-1?. Previous studies identified a class of diarylsulfonylurea containing ... -
Detecting microRNA activity from gene expression data.
O'NEILL, LUKE; CARPENTER, SUSAN (2010)ABSTRACT: BACKGROUND: MicroRNAs (miRNAs) are non-coding RNAs that regulate gene expression by binding to the messenger RNA (mRNA) of protein coding genes. They control gene expression by either inhibiting translation or ... -
Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α
O'NEILL, LUKE (2013)Interleukin-1? and Tumor Necrosis Factor ? play related, but distinct, roles in immunity and disease. Our study revealed major mechanistic distinctions in the Toll-like receptor (TLR) signaling-dependent induction for the ... -
Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy
O'NEILL, LUKE; O'LEARY, JOHN (2017)The imminent threat of viral epidemics and pandemics dictates a need for therapeutic approaches that target viral pathology irrespective of the infecting strain. Reactive oxygen species are ancient processes that ... -
The GOLD Domain-containing Protein TMED1 Is Involved in Interleukin-33 Signaling.
O'NEILL, LUKE (2013)The proinflammatory danger signal IL-33, which is released from damaged or dying cells, achieves its effects via the IL-1R family member ST2L. The detection of IL-33 by ST2L initiates downstream signaling pathways that ... -
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity
O'NEILL, LUKE (2017)Glutathione transferase Omega 1 (GSTO1-1) is an atypical GST reported to play a pro-inflammatory role in response to LPS. Here we show that genetic knockout of Gsto1 alters the response of mice to three distinct ... -
The history of Toll-like receptors-redefining innate immunity
O'NEILL, LUKE; BOWIE, ANDREW (2013)The discovery of Toll-like receptors (TLRs) was an important event for immunology research and was recognized as such with the awarding of the 2011 Nobel Prize in Physiology or Medicine to Jules Hoffmann and Bruce Beutler, ... -
How metabolism generates signals during innate immunity and inflammation
MCGETTRICK-DILLON, ANNE; O'NEILL, LUKE (2013)The interplay between immunity, inflammation, and metabolic changes is a growing field of research. Toll-like receptors and NOD-like receptors are families of innate immune receptors, and their role in the human immune ... -
IL-10 inhibits miR-155 induction by Toll-like receptors.
O'NEILL, LUKE; DOYLE, SARAH; MCCOY, CLAIRE; SHEEDY, FREDERICK JOHN; QUINN, SUSAN; SHEEDY, FREDERICK (2010)IL-10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes which are induced by Toll-like Receptor (TLR) signalling. In this study we have examined whether modulation of micro-RNAs ... -
Immunology. Sensing the dark side of DNA.
O'NEILL, LUKE (2013) -
The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for pro-inflammatory interleukins and microbial products
O'NEILL, LUKE; BOWIE, ANDREW (2000)The interleukin-1 (IL-1) receptor/Toll-like receptor (TLR) superfamily is a recently defined and expanding group of receptors that participate in host responses to injury and infection. The superfamily is defined by the ...