Cardiolipin and the Nlrp3 inflammasome.
Citation:
O'Neill LA, Cardiolipin and the Nlrp3 inflammasome., Cell metabolism, 18, 5, 2013, 610-2Download Item:
Abstract:
The Nlrp3 inflammasome is a key controller of the proinflammatory cytokine IL-1β. Iyer and colleagues (2013) demonstrate that Nlrp3 activators promote an interaction between cardiolipin in mitochondria and Nlrp3. Cardiolipin is thus a hydrophobic danger signal that, upon translocation to the outer mitochondrial membrane, activates Nlrp3, promoting inflammation.
Author's Homepage:
http://people.tcd.ie/laoneillDescription:
PUBLISHED
Author: O'NEILL, LUKE
Type of material:
Journal ArticleCollections
Series/Report no:
Cell metabolism18
5
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Full text availableKeywords:
BiochemistryDOI:
http://dx.doi.org/10.1016/j.cmet.2013.10.013ISSN:
1550-4131Metadata
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