Browsing Biochemistry (Scholarly Publications) by Author "Carty, Michael"
Now showing items 1-7 of 7
-
Activation of host pattern recognition receptors by viruses
Bowie, Andrew; Carty, Michael (2010)Viral recognition by the host innate immune system has become an exciting and growing area of research focus in recent years. It is now apparent that multiple pattern recognition receptor (PRR) families, including Toll-like ... -
CRISPR/Cas9-mediated SARM1 knockout and epitope-tagged mice reveal that SARM1 does not regulate nuclear transcription, but is expressed in macrophages
Carty, Michael; Kelly, Vincent; Bowie, Andrew; Hokamp, Karsten (2021)SARM1 is a toll/interleukin-1 receptor -domain containing protein, with roles proposed in both innate immunity and neuronal degeneration. Murine SARM1 has been reported to regulate the transcription of chemokines in both ... -
Detection of Viral Infections by Innate Immunity
Carty, Michael; Bowie, Andrew (2021)Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral innate immune system as they detect conserved viral pathogen-associated molecular patterns (PAMPs). A successful host response to viral ... -
Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
Mills, Kingston; Carty, Michael; Ni Cheallaigh, Cliona (2023)Excessive inflammation-associated coagulation is a feature of infectious diseases, occurring in such conditions as bacterial sepsis and COVID-19. It can lead to disseminated intravascular coagulation, one of the leading ... -
Evaluating the role of Toll-like Receptors in diseases of the Central Nervous system
Bowie, Andrew; Carty, Michael (2011)A key part of the innate immune system is a network of pattern recognition receptors (PRRs) and their associated intracellular signalling pathways. Toll-like receptors (TLRs) are one such group of PRRs that detect pathogen ... -
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
Carty, Michael (2006)Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor ... -
SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter.
Bowie, Andrew; Carty, Michael (2014)The four Toll/IL-1R domain-containing adaptor proteins MyD88, MAL, TRIF, and TRAM are well established as essential mediators of TLR signaling and gene induction following microbial detection. In contrast, the function of ...