Browsing Biochemistry (Theses and Dissertations) by Title
Now showing items 156-175 of 290
-
Kinetic studies on biliverdin-IXalpha reductase
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)The species distribution of biliverdin-IXa reductase (BVR-A) has been reinvestigated. It appears increasingly likely that birds and amphibia have the potential to express an active biliverdin-IXa reductase. The full length ... -
Local cellular and humoral immunity to Bordetella pertussis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)The development of whole cell vaccine (Pw) and acellular pertussis vaccines (Pa) has had a huge impact on the incidence of whooping cough worldwide. The traditional Pw had high protective efficacy, but were associated with ... -
Mal is not esential for TLR2 signalling and inhibits signalling by TLR3
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010)This thesis set out to systematically analyse the role of Mai in signalling by TLR2, TLR3 and TLR4 in murine macrophages and dendritic cells. It has revealed that Mai is not essential to TLR2 signal transduction, is required ... -
Malonylation of GAPDH in the inflammatory response in macrophages
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)Succinylation and malonylation are two recently discovered protein post-translational modifications. They involve the attachment to lysines of metabolism-derived succinyl and malonyl groups respectively, resulting in a ... -
Manipulating regulatory responses in antitumour immunity
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)The immune system has evolved tolerogenic and regulatory mechanism to control responses to self-antigens and to ensure that the inflammatory immune response to pathogens does not cause excessive tissue damage during ... -
Mechanisms of gasdermin pore formation in response to viral sensing in human respiratory epithelial cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)A key component of the innate immune response to infection or cellular stress is the activation of inflammasomes which leads to gasdermin (GSDM) pore formation, interleukin-1β (IL-1β) release and lytic cell death. GSDMs ... -
Mechanisms of immunomodulatory activity of Cholera toxin
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)Cholera toxin (CT), a major enterotoxin produced by Vibrio cholerae, is a potent mucosal adjuvant that promotes type 2 T helper cell (Th2) responses to coadministered foreign antigen. However, the mechanisms involved in ... -
Mechanistic and functional studies on biliverdin IXa reductase from the cyanobacterium synechocystis sp.PCC6803
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)The enzymes of heme metabolism and phycobilin biosynthesis in the cyanobacterium Synechocystis sp. PCC6803, along with their reducing partners, ferredoxin and ferredoxin reductase were produced through recombinant DNA ... -
Mechanistic studies on human liver Biliverdin-IX beta reductase
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)The reaction mechanism of human biliverdin-IXβ reductase (BVR-B) has been investigated using a number of approaches. The preference for NADPH over NADH has been examined using site-directed mutagenesis. The crystal structure ... -
Metabolic and redox regulation of IL-17-producing γδ T cells
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2024)Interleukin-17 (IL-17) is a proinflammatory cytokine that contributes to a wide range of immune responses, including host defence, tissue repair, autoimmune inflammation, and tumour progression. γδ17 T cells (CD3+TCRδ+CD27-) ... -
Metabolic control analysis and mitochondrial function in the nerve terminal
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2009)Reduced activities of the mitochondrial electron transport chain complexes have been implicated in the pathogenesis of numerous neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and ... -
Metabolic flux control of mitochondrial dynamics in cancer cells
(Trinity College Dublin. School of Engineering. Discipline of Electronic & Elect. Engineering, 2017) -
MicroRNA regulation of the bovine mammary immune response to a mastitis pathogen
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)Bovine mastitis is an inflammation-driven disease of the mammary gland that is associated with €2 billion in yearly losses to the European dairy industry. Streptococcus uberis is now ranked amongst the most prevalent ... -
MicroRNA-21 Limits Macrophage Responses to Mycobacterium tuberculosis
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)Mycobacterium tuberculosis (Mtb) is an intracellular pathogen that subverts the innate immune response. The Mtb pandemic is of global concern. Emerging strains of antibiotic-resistant Mtb warrant the development of ... -
Modulation of cellular immunity by Schistosoma mansoni in mice
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)Schistosoma mansoni is a trematode parasite that elicits a potent Th2 response in its mammalian host. Schistosomes are powerful stimulators and suppressors of the immune system, with these alterations in immune function ... -
Modulation of hepatic autophagy for therapeutic correction of type 2 diabetes
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Glucagon is produced from pancreatic α-cells to control hepatic glucose production and glucose homeostasis. Hyperglycaemia is an early hallmark of type 2 diabetes, and therefore hepatic glucose production can contribute ... -
Modulation of immune responses by Fasciola hepatica-derived products
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)Helminths are successful pathogens that infect 25% of the world s population. They cause chronic infections that are associated with type-2 and regulatory immune responses that suppress host anti-parasite immune responses. ... -
Modulation of immune responses by filamentous haemagglutinin from Bordetella pertussis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2004)The aim of this study was to investigate the mechanisms by which filamentous haemagglutinin (FHA) from Bordetella pertussis modulates immune responses. FHA is an adhesion molecule of B. pertussis and facilitates bacterial ... -
Modulation of innate and adaptive anti-tumour immune responses
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)Cancer is the second leading cause of death in the developed world after cardiovascular disease, with almost 25 million people living with cancer worldwide. The three main therapeutic approaches for the treatment of cancer ... -
Modulation of innate and adaptive immune responses by adenylate cyclase toxin from Bordetella pertussis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2006)CyaA belongs to the repeat-in-toxin (RTX) family of pore-forming toxins that require posttranslational acyiation to lyse eukaryotic cells. While it was known that CyaA binds to a variety of cell types, catalyses the ...
