Dissociation of dorsal hippocampal regional activation under the influence of stress in freely behaving rats.
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2011Citation:
Passecker J, Hok V, Della-Chiesa A, Chah E, O'Mara SM, Dissociation of dorsal hippocampal regional activation under the influence of stress in freely behaving rats., Frontiers in Behavioral Neuroscience, 5, 2011, 66-Download Item:
Abstract:
Stress has deleterious effects on brain, body, and behavior in humans and animals alike. The present work investigated how 30-min acute photic stress exposure impacts on spatial information processing in the main sub-regions of the dorsal hippocampal formation [CA1, CA3, and dentate gyrus (DG)], a brain structure prominently implicated in memory and spatial representation. Recordings were performed from spatially tuned hippocampal and DG cells in rats while animals foraged in a square arena for food. The stress procedure induced a decrease in firing frequencies in CA1 and CA3 place cells while sparing locational characteristics. In contrast to the CA1-CA3 network, acute stress failed to induce major changes in the DG neuronal population. These data demonstrate a clear dissociation of the effects of stress on the main hippocampal sub-regions. Our findings further support the notion of decreased hippocampal excitability arising from behavioral stress in areas CA1 and CA3, but not in DG.
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Science Foundation Ireland (SFI)
8AA G22112
Author's Homepage:
http://people.tcd.ie/smomarahttp://people.tcd.ie/hokv
http://people.tcd.ie/dellacha
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Frontiers in Behavioral Neuroscience5
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Neuroscience, StressSubject (TCD):
NeuroscienceDOI:
http://dx.doi.org/10.3389/fnbeh.2011.00066ISSN:
1662-5153Metadata
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