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dc.contributor.authorLonergan, Peter
dc.date.accessioned2021-09-15T06:27:41Z
dc.date.available2021-09-15T06:27:41Z
dc.date.issued2020
dc.date.submitted2020en
dc.identifier.citationLonergan, P., Washington, S., Meng, M., & Eapen, R. (2020). The Clinical Applications of Tissue Biomarkers in Prostate Cancer. Société Internationale d’Urologie Journal, 1(1), 30-38en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/97073
dc.descriptionPUBLISHEDen
dc.description.abstractThe clinical course of localized prostate cancer varies widely, from indolent disease unlikely to need treatment to aggressive disease requiring intensive, multimodal therapy. Traditionally, treatment decisions have been based on clinical and pathologic factors, including serum prostate specific antigen (PSA), clinical stage, and Gleason score. However, these factors have limited ability to describe the underlying tumor biology. Tissue-based genomic tests have emerged as a promising tool to more accurately characterize prostate cancer biology and predict clinical course. Using prostate cancer tissue obtained at pre-treatment biopsy or radical prostatectomy, these tests exploit the expression of specific genes involved in key biological pathways and, as a result, have the potential to aid clinical decision-making. The current review summarizes available data describing the clinical use of 5 commercially available tissue-based genomic assays in a number of clinical scenarios.en
dc.format.extent30en
dc.format.extent38en
dc.language.isoenen
dc.relation.ispartofseriesSoci?t? Internationale d'Urologie Journal;
dc.relation.ispartofseries1;
dc.relation.ispartofseries1;
dc.rightsYen
dc.subjectProstate genomicsen
dc.subjectProstate canceren
dc.subjectBiomarkersen
dc.subjectDNA repairen
dc.subjectGene panelsen
dc.subjectGenetic testingen
dc.subjectGermline mutationen
dc.subjectPrecision medicineen
dc.subjectTissue biomarkersen
dc.titleThe Clinical Applications of Tissue Biomarkers in Prostate Canceren
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/plonerga
dc.identifier.rssinternalid233322
dc.rights.ecaccessrightsopenAccess
dc.identifier.rssurihttps://siuj.org/index.php/siuj/article/view/46
dc.identifier.orcid_id0000-0001-7233-8156
dc.status.accessibleNen


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