Show simple item record

dc.contributor.authorTajber, Lidia
dc.contributor.authorUmerska, Anita
dc.contributor.authorBialek, Klaudia
dc.contributor.authorZotova, Julija
dc.contributor.authorSkotnicki, Marcin
dc.date.accessioned2020-06-08T08:28:07Z
dc.date.available2020-06-08T08:28:07Z
dc.date.issued2020
dc.date.submitted2020en
dc.identifier.citationUmerska, A., Bialek, K., Zotova, J., Skotnicki, M. & Tajber, L., Anticrystal Engineering of Ketoprofen and Ester Local Anesthetics: Ionic Liquids or Deep Eutectic Mixtures?, Pharmaceutics, 12, 4, 2020en
dc.identifier.issn1999-4923
dc.identifier.otherY
dc.identifier.urihttps://www.mdpi.com/1999-4923/12/4/368
dc.identifier.urihttp://hdl.handle.net/2262/92739
dc.descriptionPUBLISHEDen
dc.description.abstractIonic liquids (ILs) and deep eutectic mixtures (DEMs) are potential solutions to the problems of low solubility, polymorphism, and low bioavailability of drugs. The aim of this work was to develop and investigate ketoprofen (KET)-based ILs/DEMs containing an ester local anesthetic (LA): benzocaine (BEN), procaine (PRO) and tetracaine (TET) as the second component. ILs/DEMs were prepared via a mechanosynthetic process that involved the mixing of KET with an LA in a range of molar ratios and applying a thermal treatment. After heating above the melting point and quench cooling, the formation of supercooled liquids with Tgs that were dependent on the composition was observed for all KET-LA mixtures with exception of that containing 95 mol% of BEN. The KET-LA mixtures containing either ≥ 60 mol% BEN or 95 mol% of TET showed crystallization to BEN and TET, respectively, during either cooling or second heating. KET decreased the crystallization tendency of BEN and TET and increased their glass-forming ability. The KET-PRO systems showed good glass-forming ability and did not crystallize either during the cooling or during the second heating cycle irrespective of the composition. Infrared spectroscopy and molecular modeling indicated that KET and LAs formed DEMs, but in the KET-PRO systems small quantities of carboxylate anions were present.en
dc.description.sponsorshipScience Foundation Ireland, grant number 15/CDA/3602; Science Foundation Ireland (SFI) and co-funded under the European Regional Development Fund, Synthesis and Solid State Pharmaceutical Centre (SSPC), grant number 12/RC/2275en
dc.language.isoenen
dc.relation.ispartofseriesPharmaceutics;
dc.relation.ispartofseries12;
dc.relation.ispartofseries4;
dc.rightsYen
dc.subjectIonic liquidsen
dc.subjectDeep eutectic mixturesen
dc.subjectKetoprofenen
dc.subjectNon-steroidal anti-inflammatory drugsen
dc.subjectLocal anestheticsen
dc.subjectProcaineen
dc.subjectBenzocaineen
dc.subjectTetracaineen
dc.subjectAnticrystal engineeringen
dc.subjectMechanochemistryen
dc.titleAnticrystal Engineering of Ketoprofen and Ester Local Anesthetics: Ionic Liquids or Deep Eutectic Mixtures?en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/ltajber
dc.identifier.rssinternalid216134
dc.identifier.doihttp://dx.doi.org/10.3390/pharmaceutics12040368
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.subject.TCDThemeNanoscience & Materialsen
dc.identifier.orcid_id0000-0003-1544-6796


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record