The effect of Medial Septum Stimulation on Hippocampal Electrophysiology and Behaviour of Freely Moving Rats
Citation:
OLIVEIRA, MATHEUS CAFALCHIO, The effect of Medial Septum Stimulation on Hippocampal Electrophysiology and Behaviour of Freely Moving Rats, Trinity College Dublin.School of Psychology, 2020Download Item:
Abstract:
This study focuses on the interaction between the medial septum and
hippocampus in freely moving animals. To investigate this circuit, we used
electrophysiological techniques combined with behavioural tasks.
The medial septum exerts a modulatory effect on the entire hippocampal and
parahippocampal formation. However, the role of the medial septum in spatial
processing is still poorly understood. Here, we explore the septohippocampal
circuit, focusing on electrophysiology, spatial processing and behaviour.
Our results suggest that nonselective optogenetic stimulation of the medial
septum induces inhibition of intra-septal neurons and consequently, disinhibition
of hippocampal CA1 interneurons. We also demonstrated that firing rate of medial
septal neurons is inversely proportional to the animal's speed.
Transgenic models were used to investigate the contribution of septal GABAergic
and cholinergic neurons in reward-related behaviour. We showed for the first time
that the firing of medial septal GABAergic neurons can mediate place preference
behaviour.
To investigate if medial septum neurons can modulate hippocampal spatial
processing, we recorded CA1 place cells during septal stimulation. We showed that
medial septum stimulation induces place field remapping. We also showed that
the medial septum stimulation restricted to a region of the arena was able to
induced place preference and shifted the place field assembly towards this region.
Sponsor
Grant Number
Science Without Borders - CAPES - Brazil
Author's Homepage:
https://tcdlocalportal.tcd.ie/pls/EnterApex/f?p=800:71:0::::P71_USERNAME:MAOLIVEIDescription:
APPROVED
Author: OLIVEIRA, MATHEUS CAFALCHIO
Advisor:
Tsanov, MarianO'Mara, Shane
Publisher:
Trinity College Dublin. School of Psychology. Discipline of PsychologyType of material:
ThesisAvailability:
Full text availableMetadata
Show full item recordLicences: