Synthesis and evaluation of dinuclear cyclen-based lanthanide complexes for the hydrolysis of phosphodiester bonds
Citation:
Doireann Á. Moore, 'Synthesis and evaluation of dinuclear cyclen-based lanthanide complexes for the hydrolysis of phosphodiester bonds', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2010, pp 226Download Item:
Abstract:
This thesis, entitled, "Synthesis and Evaluation of Cyclen-based Lanthanide
Complexes for the Hydrolysis of Phosphodiester Bonds" is composed of five Chapters. In
the first Chapter the structural importance of phosphodiester bonds in Nature and their
cleavage by ribonucleases is introduced. The manipulation of the hydrolysis of such
phosphodiester bonds using an artificial ribonuclease mimic for the development of a novel
genetic therapy is outlined. The use of metal ions by ribonucleases, ribozymes, and
artificial nucleases is examined and this is followed by a detailed discussion of recent
advancements in the literature of metal based ribonuclease mimics, with a particular focus
on the lanthanide metal ions. Finally, an overview of the work in this area by the
Gunnlaugsson group is given and the work detailed in this thesis is briefly outlined.
Author: Moore, Doireann Á.
Advisor:
Gunnlaughsson, ThorfinnurQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of ChemistryNote:
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Chemistry, Ph.D., Ph.D. Trinity College Dublin.Metadata
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