Browsing School of Natural Sciences by Subject "Immunology, Inflammation & Infection"
Now showing items 1-19 of 19
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Ascaris and ascariasis
(2011)Ascaris lumbricoides and Ascaris suum are widespread parasitic nematodes of humans and pigs respectively. Recent prevalence data suggests that approximately 1.2 billion people are infected. Adult worms exhibit an overdispersed ... -
Ascaris co-infection does not alter malaria-induced anaemia in a cohort of Nigerian preschool children.
(2013)BACKGROUND: Co-infection with malaria and intestinal parasites such as Ascaris lumbricoides is common. Malaria parasites induce a pro-inflammatory immune response that contributes to the pathogenic sequelae, such as ... -
Cerebral toxocariasis: Silent progression to neurogenerative disorders?
(2015)Toxocara canis and T. cati are highly prevalent nematode infections of the intestines of dogs and cats. In paratenic hosts, larvae do not mature in the intestine but instead migrate through the somatic tissues and organs ... -
A comparison of helminth infections as assessed through coprological analysis and adult worm burdens in a wild host
(2018)Coprological analysis is the most widely used diagnostic tool for helminth infection in both domestic and wild mammals. Evaluation of the efficacy of this technique is rare, due to the lack of availability of adult worm ... -
Contamination of the hair of owned dogs with the eggs of Toxocara spp
(2010)Toxocara canis is one of the most common gastrointestinal helminthes of dogs. Humans can become infected through ingestion of infective eggs, Infection often causes few symptoms but in rare cases blindness can occur. It ... -
Dose-dependent impact of larval Ascaris suum on host body weight in the mouse model
(2009)Ascaris lumbricoides and Ascaris suum are important helminth parasites of humans and pigs, respectively. Although it is now well established that the presence of mature adult worms in the host intestine contributes to ... -
Genetic influence on the kinetics and associated pathology of the early stage (intestinal-hepatic) migration of Ascaris suum in mice
(2010)The generative mechanism(s) of aggregation and predisposition to Ascaris lumbricoides and A. suum infections in their host population are currently unknown and difficult to elucidate in humans and pigs for ethical/logistical ... -
Identification of a high diversity of Cryptosporidium species, genotypes and subtypes in a Nigerian Pediatric Population
(2010)A longitudinal study was conducted to determine the epidemiology of Cryptosporidium in 1,636 children in Nigeria. Oocyst prevalence ranged from 15.6% to 19.6% over one year. Cryptosporidium hominis (34), C. parvum (25), ... -
Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial
(2010)Background: Helminth infections can alter susceptibility to malaria. Studies need to determine whether or not deworming programs can impact on Plasmodium infections in preschool children. Methods: A double-blind ... -
Investigating the underlying mechanism of resistance to Ascaris infection
(2011)The generative mechanism(s) of predisposition to Ascaris infection are currently unknown. While many factors play a role in interindividual infection intensity, much focus has been placed on the host's immunological response ... -
Patterns of soil-transmitted helminth infection and impact of four-monthly albendazole treatments in preschool children from semi-urban communities in Nigeria: a double-blind placebo-controlled randomised trial.
(2009)BACKGROUND: Children aged between one and five years are particularly vulnerable to disease caused by soil-transmitted helminths (STH). Periodic deworming has been shown to improve growth, micronutrient status (iron and ... -
Plasma cytokines, chemokines and cellular immune responses in preschool Nigerian children infected with Plasmodium falciparum
(2013)BACKGROUND: Malaria is a major cause of morbidity and mortality worldwide with over one million deaths annually, particularly in children under five years. This study was the first to examine plasma cytokines, chemokines ... -
Predisposition to ascariasis: patterns, mechanisms and implications
(2009)Ascaris lumbricoides, the human roundworm, is a remarkably infectious and persistent parasite. It is a member of the soil-transmitted helminths or geohelminths and infects in the order of 1472 million people worldwide. ... -
A proteomic investigation of hepatic resistance to Ascaris in a murine model
(2016)he helminth Ascaris causes ascariasis in both humans and pigs. Humans, especially chil- dren, experience significant morbidity including respiratory complications, growth deficits and intestinal obstruction. Given that ... -
Reduced helminth parasitism in the introduced bank vole (Myodes glareolus): More parasites lost than gained.
(2016)Introduced species are often less parasitised compared to their native counterparts and to ecologically similar hosts in the new environment. Reduced parasitism may come about due to both the loss of original parasites and ... -
The role of Intelectin-2 in resistance to Ascaris suum lung larval burdens in susceptible and resistant mouse strains
(2011)The underlying mechanism of predisposition to Ascaris infection is not yet understood but host genetics are thought to play a fundamental role. We investigated the association between the Intelectin-2 gene and resistance ... -
The significance of cerebral toxocariasis: a model system for exploring the link between brain involvement, behaviour and the immune response
(2013)Toxocara canis is a parasitic nematode that infects canines worldwide, and as a consequence of the widespread environmental dissemination of its ova in host faeces, other abnormal hosts including mice and humans are exposed ... -
Soil-transmitted helminth infections in Nigerian children aged 0-25 months
(2009)The objective of this cross-sectional study was to determine the prevalence and intensity of soil-transmitted helminths (STHs) in children aged 0?25 months and to identify the associated risk factors for Ascaris lumbricoides ... -
Sporadic Cryptosporidium infection in Nigerian children: Risk factors with species identification
(2011)A cross-sectional study was conducted to investigate risk factors for sporadic Cryptosporidium infection in a paediatric population in Nigeria. Of 692 children, 134 (19?4%) were infected with Cryptosporidium oocysts. ...