Investigations of the potential use of ruthenium-ODN conjugates as antisense agents in chronic myeloid leukaemia
Citation:
Yvonne Kavanagh, 'Investigations of the potential use of ruthenium-ODN conjugates as antisense agents in chronic myeloid leukaemia', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2002, pp 254Download Item:
Kavanagh TCD THESIS 6832 Investigations of.pdf (PDF) 179.2Mb
Abstract:
The work presented in this thesis describes the synthesis of two ruthenium
oligodeoxynucleotide (ODN) conjugates and their application as potential
photoactive antisense agents in a model Chronic Myeloid Leukaemia (CML) system.
The target 34mer ODN sequence chosen for the model system represents the
messenger RNA sequence transcribed from the breakpoint region of the bcr/abl
oncogene on the Philadelphia chromosome, an abnormal chromosome specific to
CML cells. The overall aim of this work is augmentation of an antisense effect
through site-specific photochemical targeting of the target 34mer ODN sequence
thus, in theory, suppressing leukaemic mRNA expression and subsequent oncoprotein
production.
Author: Kavanagh, Yvonne
Advisor:
Corish, JohnQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of ChemistryNote:
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Full text availableKeywords:
Chemistry, Ph.D., Ph.D. Trinity College DublinLicences: