Computational study of the a1A-adrenoceptor and its ligands
Citation:
Gemma Kinsella, 'Computational study of the a1A-adrenoceptor and its ligands', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2005, pp 224Download Item:
Abstract:
Adrenoceptors belong to the 'super-family' of seven transmembrane domain
receptors known as G protein coupled receptors (GPCRs), which produce their effects
through coupling with G proteins. Nine different subtypes of adrenoceptors (ARs) have
been identified based on the results of pharmacological and molecular cloning studies,
of which the α1-A R subtypes are associated with the condition Benign Prostatic
Hyperplasia (BPH). BPH effects 50 % of men over the age of 50 and due to increased
life expectancy the proportion of men suffering from BPH will increase significantly
over the coming years. Prostatic smooth muscle contraction occurs predominantly, if
not exclusively, via the α1A-AR subtype and antagonists selective for this particular
receptor might be most useful in alleviating the urological symptoms of BPH which
include increased frequency in urination, nocturia, a poor urine stream and hesitancy or
delay in starting flow.
Author: Kinsella, Gemma
Advisor:
Watson, GraemeQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of ChemistryNote:
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Full text availableKeywords:
Chemistry, Ph.D., Ph.D. Trinity College DublinMetadata
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