A novel synthesis of Loratadine and studies on Stobbe-like condensation reactions
Citation:
Matthias Christoph Eichler, 'A novel synthesis of Loratadine and studies on Stobbe-like condensation reactions', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2007, pp 227Download Item:
Eichler TCD THESIS 8096 A novel.pdf (PDF) 145.6Mb
Abstract:
Loratadine is one of the best-selling, non-sedative antihistamines worldwide.
Numerous papers have been published in academic and patent literature focussing
on improvements or alternatives to the original synthesis of Loratadine and its
precursors. The most significant of these synthetic approaches, including the
original synthesis of the drug, are outlined in Chapter 1. This is followed by the
presentation of a novel strategy to access an important Loratadine precursor,
3-[2'-(m-chlorophenyl)ethyl]picolinic acid, from inexpensive starting materials. The
synthesis of this precursor was the first project of this Thesis.
Author: Eichler, Matthias Christoph
Advisor:
Grayson, DavidQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of ChemistryNote:
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Full text availableKeywords:
Chemistry, Ph.D., Ph.D. Trinity College DublinLicences: