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dc.contributor.authorCusack, Rhodrien
dc.date.accessioned2019-04-05T12:34:56Z
dc.date.available2019-04-05T12:34:56Z
dc.date.issued2019en
dc.date.submitted2019en
dc.identifier.citationFuhrmann D., Nesbitt D., Shafto M., Rowe J.B., Price D., Gadie A., Tyler L.K., Brayne C., Bullmore E.T., Calder A.C., Cusack R., Dalgleish T., Duncan J., Henson R.N., Matthews F.E., Marslen-Wilson W.D., Rowe J.B., Shafto M.A., Campbell K., Cheung T., Davis S., Geerligs L., Kievit R., McCarrey A., Mustafa A., Price D., Samu D., Taylor J.R., Treder M., Tsvetanov K., van Belle J., Williams N., Bates L., Emery T., Erzinlioglu S., Gadie A., Gerbase S., Georgieva S., Hanley C., Parkin B., Troy D., Auer T., Correia M., Gao L., Green E., Henriques R., Allen J., Amery G., Amunts L., Barcroft A., Castle A., Dias C., Dowrick J., Fair M., Fisher H., Goulding A., Grewal A., Hale G., Hilton A., Johnson F., Johnston P., Kavanagh-Williamson T., Kwasniewska M., McMinn A., Norman K., Penrose J., Roby F., Rowland D., Sargeant J., Squire M., Stevens B., Stoddart A., Stone C., Thompson T., Yazlik O., Barnes D., Dixon M., Hillman J., Mitchell J., Villis L., Kievit R.A., Strong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy aging, Neurobiology of Aging, 74, 2019, 46 - 55, 46-55en
dc.identifier.issn15581497 01974580en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/86118
dc.descriptionPUBLISHEDen
dc.description.abstractCardiovascular health declines with age, increasing the risk of hypertension and elevated heart rate in middle and old age. Here, we used multivariate techniques to investigate the associations between cardiovascular health (diastolic blood pressure, systolic blood pressure, and heart rate) and white matter macrostructure (lesion volume and number) and microstructure (as measured by diffusion-weighted imaging) in the cross-sectional, population-based Cam-CAN cohort (N = 667, aged 18–88). We found that cardiovascular health and age made approximately similar contributions to white matter health and explained up to 56% of variance therein. Lower diastolic blood pressure, higher systolic blood pressure, and higher heart rate were each strongly, and independently, associated with white matter abnormalities on all indices. Body mass and exercise were associated with white matter health, both directly and indirectly via cardiovascular health. These results highlight the importance of cardiovascular risk factors for white matter health across the adult lifespan and suggest that systolic blood pressure, diastolic blood pressure, and heart rate affect white matter health via separate mechanisms.en
dc.format.extent46-55en
dc.format.extent46en
dc.format.extent55en
dc.relation.ispartofseriesNeurobiology of Agingen
dc.relation.ispartofseries74en
dc.rightsYen
dc.subjectWhite matter lesionen
dc.subjectCardiovascular healthen
dc.subjectBlood pressureen
dc.subjectHeart rateen
dc.subjectDiffusion weighted imagingen
dc.subjectAgingen
dc.titleStrong and specific associations between cardiovascular risk factors and white matter micro- and macrostructure in healthy agingen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/cusackrhen
dc.identifier.rssinternalid200565en
dc.identifier.doihttp://dx.doi.org/10.1016/j.neurobiolaging.2018.10.005en
dc.rights.ecaccessrightsopenAccess
dc.identifier.orcid_id0000-0002-5234-7415en


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