Non-single quantum MRI : a cardiac modulated rhythm in the brain tissue
Citation:
David López Pérez, 'Non-single quantum MRI : a cardiac modulated rhythm in the brain tissue', [thesis], Trinity College. Institute of Neuroscience, 2016Download Item:
Abstract:
The relation between pressure and ow is one of the key concepts to understand brain dynamics. The Navier-Stokes equations state how changes in flow are related to changes in pressure. In addition, the Monro-Kellie hypothesis shows that the cranium and its constituents create a state of volume equilibrium, such that any increase in volume of one of the cranial constituents must be compensated by a decrease in volume of another. Normally, pressure measurements are carried out in large arteries or CSF compartments and therefore these measurements are not able to estimate fast dynamics and pressure related changes in the brain tissue. For that reason, the focus of this work is to introduce a new MRI-based technique called Non-Single Quantum MRI. This technique investigates brain dynamics in a completely new fashion and adds additional information to the ow-pressure relationship. This work focuses on the interplay between the cardiac pressure wave and the tissue response to it. This thesis explains how the brain tissue reacts to the cardiac pressure wave. This thesis describes the basis of the author's hypotheses on the origin of the MRI contrast mechanism of the cardiac induced oscillation and presents the results of several studies carried out throughout the PhD research period. These results show that the obtained cardiac modulated MRI signal cannot be explained by
conventional MRI. A model is proposed to justify the foundation of this signal.
Moreover, differences in the tissue response were found among separated groups such as young, old or depressed participants. Finally the author provides guidelines and recommendations for future research on cardiac induced oscillations in the brain tissue. Further research paths are identified and a roadmap for future research in this area is defined.
Author: López Pérez, David
Advisor:
Kerskens, ChristianQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College. Institute of NeuroscienceNote:
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Neuroscience, Ph.D., Ph.D. Trinity College DublinMetadata
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