TCIN (Trinity College Institute of Neuroscience)
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The role of innate immune cells in the pathogenesis of experimental autoimmune encephalomyelitis
(Trinity College. Institute of Neuroscience, 2015)Experimental autoimmune encephalomyelitis (EAE) is a widely exploited animal model of multiple sclerosis (MS) and is a valuable tool in understanding the cellular and molecular basis of autoimmunity and inflammation in the ... -
Non-single quantum MRI : a cardiac modulated rhythm in the brain tissue
(Trinity College. Institute of Neuroscience, 2016)The relation between pressure and ow is one of the key concepts to understand brain dynamics. The Navier-Stokes equations state how changes in flow are related to changes in pressure. In addition, the Monro-Kellie hypothesis ... -
An investigation into stress response axis, serotonin system and adaptive immunity in depression : a focus on early life adversity and epigenetic mechanisms
(Trinity College. Institute of Neuroscience, 2017)Major depressive disorder (MDD) is a debilitating psychiatric illness that affects at least 350 million individuals worldwide. Despite its high prevalence rate and its large global disease burden, the biological mechanisms ... -
An investigation of kynurenine pathway metabolism, the hypothalamic-pituitary-adrenal axis, and inflammatory markers in Major Depressive Disorder
(Trinity College. Institute of Neuroscience, 2017)Major Depressive Disorder (MDD) is a debilitating mental health problem with a lifetime prevalence rate of more than 16%. Despite its prevalence, a biological mechanism accounting for all aspects of the disorder has yet ... -
A Langevin equation approach to diffusion magnetic resonance imaging
(Trinity College. Institute of Neuroscience, 2010)Diffusion-weighted magnetic resonance imaging (DW MRI) is a noninvasive technique which is sensitive to the translational motion of water molecules because of their Brownian motion, allowing us to probe the microstructure ...