Browsing Genetics by Author "MC LYSAGHT, AOIFE"
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Evolution of Vertebrate Tissues Driven by Differential Modes of Gene Duplication.
MC LYSAGHT, AOIFE (2012)In this study, we investigated the evolution of vertebrate tissues by examining the potential association among gene expression, duplication, and base substitution patterns. In particular, we compared whole-genome duplication ... -
Genomic Features in the Breakpoint Regions between Syntenic Blocks
MC LYSAGHT, AOIFE (Oxford University Press, 2004)MOTIVATION: We study the largely unaligned regions between the syntenic blocks conserved in humans and mice, based on data extracted from the UCSC genome browser. These regions contain evolutionary breakpoints caused by ... -
Mammalian X chromosome inactivation evolved as a dosage-compensation mechanism for dosage-sensitive genes on the X chromosome.
MC LYSAGHT, AOIFE (2012)How and why female somatic X-chromosome inactivation (XCI) evolved in mammals remains poorly understood. Ohno proposed a two-step process where XCI is a dosage-compensation mechaQ: 7 nism that evolved to equalize ... -
De novo origin of protein-coding genes in murine rodents.
MC LYSAGHT, AOIFE (2012)Background: New genes in eukaryotes are created through a variety of different mechanisms. De novo origin from non-coding DNA is a mechanism that has recently gained attention. So far, de novo genes have been described in ... -
Porter: a new, accurate server for protein secondary structure prediction
MC LYSAGHT, AOIFE (Oxford University Press, 2005)Porter is a new system for protein secondary structure prediction in three classes. Porter relies on bidirectional recurrent neural networks with shortcut connections, accurate coding of input profiles obtained from multiple ... -
Positionally biased gene loss after whole genome duplication: evidence from human, yeast, and plant.
MC LYSAGHT, AOIFE (2012)Whole genome duplication (WGD) has made a significant contribution to many eukaryotic genomes including yeast, plants and vertebrates. Following WGD, some ohnologs (WGD paralogs) remain in the genome arranged in blocks ... -
A survey of host range genes in poxvirus genomes.
MC LYSAGHT, AOIFE (2013)Poxviruses are widespread pathogens, which display extremely different host ranges. Whereas some poxviruses, including variola virus, display narrow host ranges, others such as cowpox viruses naturally infect a wide range ...