Browsing Genetics by Sponsor "Irish Research Council for Science and Engineering Technology (IRCSET)"
Now showing items 1-4 of 4
-
Functional Diversification of the Twin-Arginine Translocation Pathway Mediates the Emergence of Novel Ecological Adaptations
(2011)Microorganisms occupy a myriad of ecological niches that show an astonishing diversity. The molecular mechanisms underlying microbes? ecological diversity remain a fundamental conundrum in evolutionary biology. Evidence ... -
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
(2012)Polycomb group proteins are repressive chromatin modifiers with essential roles in metazoan development, cellular differentiation and cell fate maintenance. How Polycomb proteins access active chromatin to confer transcriptional ... -
Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90)
(2010)Retinitis pigmentosa (RP) is the most prevalent cause of registered visual handicap among working aged populations of developed countries. Up to 40% of autosomal dominant cases of disease are caused by mutations within the ... -
Understanding the diverse roles of polycomb-like proteins in the regulation of chromatin and transcriptional landscapes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)The Polycomb repressive complex 2 (PRC2) is a multiprotein chromatin modifying complex that is essential for vertebrate development and frequently deregulated in cancer. In higher eukaryotes, PRC2 is responsible for all ...