Browsing Genetics by Author "Bracken, Adrian"
Now showing items 1-8 of 8
-
A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.
Mc Lysaght, Aoife; Bracken, Adrian; Martin, Seamus (2015)Polycomb-like proteins 1-3 (PCL1-3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three ... -
A "Complex" Issue: Deciphering the Role of Variant PRC1 in ESCs.
Bracken, Adrian (2013)Several noncanonical type-1 Polycomb Repressive Complexes (PRC1) that act independently of PRC2 have been recently identified, but their functions in embryonic stem cells (ESCs) are unclear. Two recent reports by Morey et ... -
Dangerous Liaisons: Interplay between SWI/SNF, NuRD and Polycomb in Chromatin Regulation and Cancer.
Bracken, Adrian (2019)Changes in chromatin structure mediated by ATP-dependent nucleosome remodelers and histone modifying enzymes are integral to the process of gene regulation. Here, we review the roles of the SWI/SNF (switch/sucrose ... -
A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities
Bracken, Adrian; Mc Lysaght, Aoife; Hokamp, Karsten (2018)The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3. Whereas two distinct forms exist, PRC2.1 ... -
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
Bracken, Adrian (2012)Polycomb group proteins are repressive chromatin modifiers with essential roles in metazoan development, cellular differentiation and cell fate maintenance. How Polycomb proteins access active chromatin to confer transcriptional ... -
PRC2 functions in development and congenital disorders
Bracken, Adrian; Deevy, Orla (2019)Polycomb repressive complex 2 (PRC2) is a conserved chromatin regulator that is responsible for the methylation of histone H3 lysine 27 (H3K27). PRC2 is essential for normal development and its loss of function thus results ... -
Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells.
Bracken, Adrian (2021)Driver mutations in genes encoding histone H3 proteins resulting in p.Lys27Met substitutions (H3-K27M) are frequent in pediatric midline brain tumors. However, the precise mechanisms by which H3-K27M causes tumor initiation ... -
Structural basis for PRC2 engagement with chromatin
Bracken, Adrian (2020)The polycomb repressive complex 2 (PRC2) is a conservedmultiprotein, repressive chromatin complex essential fordevelopment and maintenance of eukaryotic cellular identity.PRC2 comprises a trimeric core of SUZ12, EED and ...