Browsing Genetics by Author "Bowie, Andrew"
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SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration
Carty, Michael; Farrar, Gwyneth; Bowie, Andrew (2022)The challenge of developing gene therapies for genetic forms of blindness is heightened by the heterogeneity of these conditions. However, mechanistic commonalities indicate key pathways that may be targeted in a ... -
SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration
Monaghan, Michael; Doyle, Sarah; Humphries, Peter; Carty, Michael; Bowie, Andrew; Campbell, Matthew; Humphries, Marian (2020)Retinal degeneration is the leading cause of incurable blindness worldwide and is characterised by progressive loss of light-sensing photoreceptors in the neural retina. SARM1 is known for its role in axonal degeneration, ...