Browsing Genetics by Title
Now showing items 398-417 of 553
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Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
(2012)Polycomb group proteins are repressive chromatin modifiers with essential roles in metazoan development, cellular differentiation and cell fate maintenance. How Polycomb proteins access active chromatin to confer transcriptional ... -
Population and genomic variation of immune genes in chicken
(Trinity College (Dublin, Ireland). Department of Genetics, 2010)Achieving an understanding of the processes shaping diversity at chicken immune genes illuminates their population history, relevance to disease and mechanisms of evolution. Functional variation at genes that determine the ... -
Population genetics of modern and ancient cattle
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)The domestication of cattle was a milestone in human history. It is widely accepted that cattle were domesticated in at least two independent domestication events; the Fertile Crescent was the primary domestication centre ... -
The population genomics of archaeological transition in west Iberia: Investigation of ancient substructure using imputation and haplotype-based methods
(2017)We analyse new genomic data (0.05–2.95x) from 14 ancient individuals from Portugal distributed from the Middle Neolithic (4200–3500 BC) to the Middle Bronze Age (1740–1430 BC) and impute genomewide diploid genotypes in ... -
Porter: a new, accurate server for protein secondary structure prediction
(Oxford University Press, 2005)Porter is a new system for protein secondary structure prediction in three classes. Porter relies on bidirectional recurrent neural networks with shortcut connections, accurate coding of input profiles obtained from multiple ... -
Positionally biased gene loss after whole genome duplication: evidence from human, yeast, and plant.
(2012)Whole genome duplication (WGD) has made a significant contribution to many eukaryotic genomes including yeast, plants and vertebrates. Following WGD, some ohnologs (WGD paralogs) remain in the genome arranged in blocks ... -
Post-polyploidy evolution in yeasts
(Trinity College (Dublin, Ireland). Department of Genetics, 2007)Whole-genome duplication (WGD) and gene duplication are topics central to the study of genome evolution. With the availability of genome sequences for both paleopolyploid (post-WGD) and non-polyploid outgroup (pre-WGD) ... -
PRC2 functions in development and congenital disorders
(2019)Polycomb repressive complex 2 (PRC2) is a conserved chromatin regulator that is responsible for the methylation of histone H3 lysine 27 (H3K27). PRC2 is essential for normal development and its loss of function thus results ... -
Preservation of genetic and regulatory robustness in ancient gene duplicates of Saccharomyces cerevisiae.
(2014)Biological systems remain robust against certain genetic and environmental challenges. Robustness allows the exploration of ecological adaptations. It is unclear what factors contribute to increasing robustness. Gene ... -
Prevention of autosomal dominant retinitis pigmentosa by systemic drug therapy targeting heat shock protein 90 (Hsp90)
(2010)Retinitis pigmentosa (RP) is the most prevalent cause of registered visual handicap among working aged populations of developed countries. Up to 40% of autosomal dominant cases of disease are caused by mutations within the ... -
Primary open-angle glaucoma: on the development of novel therapeutic approaches
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Glaucoma is one of the most prevalent forms of preventable blindness, affecting more than 60 million people worldwide. While normotensive forms of the disease do exist, the majority of cases are caused by elevations in ... -
PRMT4 Is a Novel Coactivator of c-Myb-Dependent Transcription in Haematopoietic Cell Lines
(2013)Protein arginine methyltransferase 4 (PRMT4)–dependent methylation of arginine residues in histones and other chromatin- associated proteins plays an important role in the regulation of gene expression. However, the exact ... -
Production of biologically active IL-36 family cytokines through insertion of N-terminal caspase cleavage motifs
(2016)Recent evidence has strongly implicated IL-36 cytokines as key initiators of inflammation in the skin barrier. IL-36 cytokines belong to the extended IL-1 family and, similar to most members of this family, are expressed ... -
Properties and therapeutic implications of an enigmatic d477g rpe65 variant associated with autosomal dominant retinitis pigmentosa
(2020)RPE65 isomerase, expressed in the retinal pigmented epithelium (RPE), is an enzymatic component of the retinoid cycle, converting all-trans retinyl ester into 11-cis retinol, and it is essential for vision, because it ... -
Protein coadaptation and the design of novel approaches to identify protein-protein interactions
(2011)Proteins rarely function in isolation but they form part of complex networks of interactions with other proteins within or among cells. The importance of a particular protein for cell viability is directly dependent upon ... -
Proteome-Wide Analysis of Functional Divergence in Bacteria: Exploring a Host of Ecological Adaptations
(2012)Functional divergence is the process by which new genes and functions originate through the modification of existing ones. Both genetic and environmental factors influence the evolution of new functions, including gene ... -
Pseudogenes Provide Evolutionary Evidence for the Competitive Endogenous RNA Hypothesis
(2018)The competitive endogenous RNA (ceRNA) hypothesis is an attractively simple model to explain the biological role of many putatively functionless noncoding RNAs. Under this model, there exist transcripts in the cell whose ... -
PubCrawler: keeping up comfortably with PubMed and GenBank
(Oxford University Press, 2004)The free PubCrawler web service (http://www.pubcrawler.ie) has been operating for five years and so far has brought literature and sequence updates to over 22 000 users. It provides information on a personalized web page ... -
Rate asymmetry after genome duplication causes substantial long-branch attraction artifacts in the phylogeny of Saccharomyces species
(Oxford University Press, 2006)Whole-genome duplication (WGD) produces sets of gene pairs that are all of the same age. We therefore expect that phylogenetic trees that relate these pairs to their orthologs in other species should show a single consistent ... -
Rational design of artificial genetic switches : co-option of H-NS-repressed operons by the VirB virulence master regulator
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)The H-NS protein represses the transcription of hundreds of genes in Gram-negative bacteria. De-repression is achieved by a multitude of mechanisms, many of which involve binding of a protein to DNA at the repressed promoter ...