Browsing Genetics by Title
Now showing items 310-329 of 552
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Mitochondrial fission/fusion dynamics and apoptosis
(2010)Mitochondria play an important role in the progression of apoptosis through the release of pro-apoptotic factors, such as cytochrome c, from the mitochondrial intermembrane space. During this process, mitochondrial networks ... -
Mitochondrial fusion : Bax to the Fussure
(2011)Mitochondria can be organized into highly interconnected networks through continuous cycles of fission and fusion. A recent study by Hoppins et al. (2011) published in Molecular Cell now suggests that Bax, more commonly ... -
Mitochondrial genes associated with cytoplasmic male sterility in Lolium perenne
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)This study involved molecular investigations of cytoplasmic male sterility (CMS) in perennial ryegrass (Lolium perenne L). The CMS line originated as an interspecific hybrid between L. perenne (male parent) and Festuca ... -
A model system for studying the transcriptomic and physiological changes associated with mammalian host-adaptation by Leptospira interrogans serovar Copenhageni.
(2014)Leptospirosis, an emerging zoonotic disease with worldwide distribution, is caused by spirochetes belonging to the genus Leptospira . More than 500,000 cases of severe leptospirosis are reported annually, with . 10% ... -
Modulating oxidative stress in the retina using gene therapy as a potential treatment for inherited retinopathies
(Trinity College (Dublin, Ireland). Department of Genetics, 2014)The focus of this thesis was the exploration of genetic modulators of oxidative stress in transgenic mouse models of Retinitis Pigmentosa (RP). This disease can be inherited both dominantly and recessively and can be either ... -
Modulation of mitochondrial function as a therapeutic strategy for Stargardt disease and an exploration of the genetic architecture of Stargardt disease in Ireland
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Inherited retinal degenerations (IRDs) are an extremely heterogeneous group of disorders, together representing the most common cause for vision loss in young people. An estimated 5.5 million people globally are living ... -
Modulation of the blood-brain barrier for therapeutic benefit
(Trinity College (Dublin, Ireland). Department of Genetics, 2014)To date this lab has carried out novel work in the area of low-molecular weight (<1 kDa) drug delivery to the retina (Campbell, Nguyen et al. 2009; Tam, Kiang et al. 2010). This work was carried by suppression of claudin-5 ... -
Molecular and quantative analyses of genetic variation in farmed Atlantic salmon
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)Genetic diversity between three farmed and four wild populations and within six 6 year classes of one farmed population of Atlantic salmon were analysed using 15 microsatellite markers. High levels of polymorphism were ... -
The molecular chaperone dnak is a source of mutational robustness
(2016)Molecular chaperones, also known as heat-shock proteins, refold misfolded proteins and help other proteins reach their native conformation. Thanks to these abilities, some chaperones, such as the Hsp90 protein or the ... -
Molecular Engineering of Free-Base Porphyrins as Ligands-The N-H? ? ? X Binding Motif in Tetrapyrroles
(2019)The core N-H units of planar porphyrins are often inaccessible to forming hydrogen-bonding complexes with acceptor molecules. This is due to the fact that the amine moieties are “shielded” by the macrocyclic system, ... -
Molecular evolution of psbA gene in ferns: Unraveling selective pressure and co-evolutionary pattern
(2012)Abstract Background: The photosynthetic oxygen-evolving photo system II (PS II) produces almost the entire oxygen in the atmosphere. This unique biochemical system comprises a functional core complex that is encoded ... -
Molecular evolution of rbcL in three gymnosperm families: Identifying adaptive and coevolutionary patterns
(2011)Background: The chloroplast-localized ribulose-1, 5-biphosphate carboxylase/oxygenase (Rubisco), the primary enzyme responsible for autotrophy, is instrumental in the continual adaptation of plants to variations in ... -
Molecular genetic investigations of the diversity and origins of Old and New World cattle population
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)One hundred and forty-nine Bos indicus mitochondrial DNA (mtDNA) control region sequences sampled from the Indian subcontinent, the Near East and East Asia were assessed in order to investigate the domestic origins and ... -
Molecular inversion probe-based sequencing of ush2a exons and splice sites as a cost-effective screening tool in ush2 and arrp cases
(2021)A substantial proportion of subjects with autosomal recessive retinitis pigmentosa (arRP) or Usher syndrome type II (USH2) lacks a genetic diagnosis due to incomplete USH2A screening in the early days of genetic testing. ... -
Morphological characterization of the retina of the CNGA3(-/-)Rho(-/-) mutant mouse lacking functional cones and rods
(Association for Research in Vision and Ophthalmology, 2004)PURPOSE. To assess the structural changes in the retina caused by a functional blockade of rods and cones and to document the time course of their degeneration. METHODS. Double knockout mice were generated by cross-breeding ... -
Motor axon guidance in Drosophila
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The Multilayered Prehistory of Wild Aurochs and Domestic Cattle
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)This thesis explores 122 ancient genomes of domestic cattle and wild aurochs to investigate past population events such as domestication and admixture. Population genomics of ancient taurine domestics from the ancient Near ... -
Multiple rounds of speciation associated with reciprocal gene loss in polyploid yeasts.
(2006)A whole-genome duplication occurred in a shared ancestor of the yeast species Saccharomyces cerevisiae, Saccharomyces castellii and Candida glabrata. Here we trace the subsequent losses of duplicated genes, and show that ...