Browsing Genetics by Title
Now showing items 16-35 of 552
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Alternative routes to optimal expression levels: Evolutionary evidence for competitive RNAs and dosage compensation by gene duplication
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)Expression evolution and dosage constraints are important factors shaping genomic content and innovation. It has become increasingly clear that non-coding RNAs perform various regulatory functions in different cellular ... -
Amino acid identity at one position within the alpha1 helix of both the histidine kinase and the response regulator of the WalRK and PhoPR two-component systems plays a crucial role in the specificity of phosphotransfer.
(2010)Two-component systems usually function as cognate pairs, thereby ensuring an appropriate response to the detected signal. The ability to exclusively phosphorylate a partner protein, often in the presence of many competing ... -
An examination of Serotonergic candidate genes in Attention Deficit Hyperactivity Disorder
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Attention Deficit Hyperactivity Disorder (ADHD) is a common, highly heritable childhood disorder. It is characterised by symptoms of inattention, hyperactivity, and impulsivity. Heritability of ADHD is estimated to be ... -
An investigation into the complex genetics of bipolar affective disorder : potential susceptibility loci and candidate genes from the Irish population
(Trinity College (Dublin, Ireland). Department of Genetics, 2008)Bipolar affective disorder (BPAD) is a serious and debilitating psychiatric illness characterised by extreme changes in mood, ranging from depression to mania. BPAD is undoubtedly caused by genetic factors, with some ... -
An investigation of the role of caspase-9-interacting proteins in the molecular control of apoptosis
(Trinity College (Dublin, Ireland). Department of Genetics, 2001)Apoptosis is an important homeostatic mechanism that multicellular organisms utilize to delete cells during development and on an ongoing basis in the adult. At the molecular level, this requires the activation of a family ... -
An investigation of the specificity of interaction in two-component systems using YycFG and PhoPR of Bacillus subtilis as a model system
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2009)Presented in this thesis is a study of the specificity of interaction between histidine kinases and response regulators in two-component systems using YycFG and PhoPR as model system in B. subtilis. -
Analysis of gene evolution and metabolic pathways using the Candida Gene Order Browser.
(BioMed Central, 2010)Background: Candida species are the most common cause of opportunistic fungal infection worldwide. Recent sequencing efforts have provided a wealth of Candida genomic data. We have developed the Candida Gene Order Browser ... -
Analysis of stage-specific gene perturbations and characterisation of two novel F-box genes during flower development in Arabidopsis thaliana
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)The model plant Arabidopsis thaliana has been used for past three decades to study the genetic and molecular processes underlying floral organogenesis. Flowers of this small plant consist of four concentric whorls, containing ... -
Analysis of the gene regulatory network underlying reproductive floral organ development through gene perturbation experiments
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)Homeosis or homeotic transformation refers to the formation of one body structure or organ in place of another. For more than two decades, the floral homeotic genes have been at the center of intense studies that showed ... -
Ancient Genomics and Human Health
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2024)Studies of ancient DNA over the last decade have been pivotal in answering archaeological, evolutionary and ecological questions. More recently, this data has also been used in the analysis of human health in the past, in ... -
Ancient Goat Genomics: Structure, Selection, and Admixture
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2019)The wild bezoar Capra aegagrus was brought under human control c. 8,000 BC, leading to the domestic goat Capra hircus. This livestock species remains in use 10,000 years later, and is of particular importance to communities ... -
Ancient pigs reveal a near-complete genomic turnover following their introduction to Europe
(2019)Archaeological evidence indicates that pig domestication had begun by ∼10,500 y before the present (BP) in the Near East, and mitochondrial DNA (mtDNA) suggests that pigs arrived in Europe alongside farmers ∼8,500 y BP. A ... -
Angiogenin Levels and ANG Genotypes: Dysregulation in Amyotrophic Lateral Sclerosis
(2010)Objective: To determine whether 5 single nucleotide polymorphisms (SNPs) associate with ALS in 3 different populations. We also assessed the contribution of genotype to angiogenin levels in plasma and CSF. Methods: Allelic ... -
Apoptosis gene profiling reveals spatio-temporal regulated expression of the p53/Mdm2 pathway during lens development.
(2009)Evidence is emerging for apoptosis gene expression in the lens during development. Therefore, here we used a filter array to assess expression of 243 apoptosis-related genes in the developing postnatal mouse lens using ... -
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2
(2001)Smac/DIABLO is a mitochondrial protein that potentiates some forms of apoptosis, possibly by neutralizing one or more members of the IAP family of apoptosis inhibitory proteins. Smac has been shown to exit mitochondria and ... -
Automated annotation of yeast genomes
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)I have built an automated annotation pipeline (named YGAP - Yeast Genome Annotation Pipeline), designed specifically for new yeast genome sequences lacking transcriptome data. YGAP uses homology and synteny information ... -
Autophagy in Multiple Myeloma: What Makes You Stronger Can Also Kill You.
(2013)Autophagy, a process for recycling cellular constituents, is normally associated with cell survival and is thought to be beneficial for tumor maintenance. However, in this issue of Cancer Cell, Lamy and colleagues report ...