A study on novel pyrazine-substituted dithiolene complexes as synthetic models for molybdenum cofactor and facile molybdenum mediated unexpected formation of pentathiepins
Citation:
Muhammad Zubair, 'A study on novel pyrazine-substituted dithiolene complexes as synthetic models for molybdenum cofactor and facile molybdenum mediated unexpected formation of pentathiepins', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2014, pp 207Download Item:
Zubair TCD THESIS 10522 A study.pdf (PDF) 105.4Mb
Abstract:
In the present study, pyrazine (3 and 12) and quinoxaline (4 and 9-11) based compounds were synthesised as precursors for the synthetic analogues of MPT in MoCo. During the attempts to synthesise target model complexes, an unexpected formation of quinoxaline-derived pentathiepin (15) was observed. This by chance invented method for preparation of pentathiepin was optimised and then used to synthesise a series of other pentathiepin derivatives (16-18). Further on, a study has been made with regard to evaluate the influence of different substituents on the biological properties of these compounds. All pentathiepin derivatives (15-18) exhibited promising DNA binding properties as a minor groove binding agents and remarkable therapeutic activities.
Author: Zubair, Muhammad
Advisor:
Schulzke, CarolaBaker, Robert
Qualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of ChemistryNote:
TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ieType of material:
thesisAvailability:
Full text availableKeywords:
Chemistry, Ph.D., Ph.D. Trinity College DublinLicences: