Antinociceptive Activity of Zanthoxylum piperitum DC. Essential Oil
Citation:
Donald, GR; Fernandes PD; Boylan, F, Antinociceptive Activity of Zanthoxylum piperitum DC. Essential Oil, Evidence-based Complementary and Alternative Medicine, 1, 1, 2016, 3840398-Download Item:
3840398.pdf (PDF) 1.550Mb
Abstract:
Zanthoxylum piperitum DC. (ZP) is a traditional medicinal plant used mainly in countries from Asia such as Japan. This study
aimed to investigate the antinociceptive effect of ZP essential oil (ZPEO).Themajor component present in the essential oil was betaphellandrene
(29.39%). Its antinociceptive activity was tested through animalmodels (formalin-, capsaicin-, and glutamate-induced
paw licking and hot plate).The anti-inflammatory effect was evaluated through the carrageenan-induced leukocyte migration into
the subcutaneous air pouch (SAP), with measurement of cytokines. The results showed antinociceptive effect for ZPEO for the
first phase of the formalin-induced licking, glutamate, and hot plate tests. However, ZPEO had no effect on reducing paw licking
induced by capsaicin. Finally, ZPEO had no effect against inflammation induced by carrageenan.
Sponsor
Grant Number
Science Foundation Ireland (SFI)
SFI/13/ISCA/2843
Author's Homepage:
http://people.tcd.ie/desouzafDescription:
PUBLISHED
Author: BOYLAN, FABIO
Type of material:
Journal ArticleSeries/Report no:
Evidence-based Complementary and Alternative Medicine1
1
Availability:
Full text availableKeywords:
Zanthoxylum piperitum DC.Subject (TCD):
Immunology, Inflammation & Infection , International Integration , Ethnopharmacology , PHARMACOLOGY , Phytochemistry & Natural ProductsDOI:
http://dx.doi.org/10.1155/2016/3840398ISSN:
1741-427XLicences: