Analysis of the modulatory effects of amyloid-beta and age on microglial activation
Citation:
Julie-Ann O'Reilly, 'Analysis of the modulatory effects of amyloid-beta and age on microglial activation', [thesis], Trinity College. Institute of Neuroscience, 2009, pp 307Download Item:
Abstract:
Microglia are the resident immune cells of the brain, and in the healthy brain they are believed to be responsible for the clearance of amyloid-beta (Aβ). Age is a primary risk factor for Alzheimer’s disease (AD) and the age-related proinflammatory environment is thought to contribute to the pathogenesis of AD. In AD, activated microglia have been shown to be associated with insoluble Aβ plaques, but whether they play a role in phagocytosis of Aβ in this context is not known. Both inflammatory molecules and Aβ can trigger neurodegenerative changes and both exert a negative impact on memory. Therefore it is believed that both play a crucial role in the pathogenesis of AD.
Author: O'Reilly, Julie-Ann
Advisor:
Lynch, MarinaQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College. Institute of NeuroscienceNote:
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Full text availableKeywords:
Neuroscience, Ph.D., Ph.D. Trinity College DublinMetadata
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