Browsing Mechanical, Manufacturing & Biomedical Eng by Sponsor "Science Foundation Ireland (SFI)"
Now showing items 1-20 of 119
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A 12 month prospective cohort study of injury in international rowers.
(2010)Objective: In this study, the injury incidence and association with type and volume of training in international rowers were described. Design: A prospective cohort design was used over a 12- month period. Patients: ... -
3D Bioprinted Cartilaginous Templates as Developmentally Inspired Implants for Large Bone Defect Regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Whilst bone possesses an inherent capacity for regeneration, defects above a critical size cannot heal on their own. Damaged or diseased bone can be treated using autografts or a range of different bone grafting biomaterials, ... -
3D Bioprinting of Developmentally Inspired Templates for Bone and Joint Regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)There is an urgent need to develop alternatives to synthetic joint prosthesis to promote the regeneration of diseased osteoarthritic joints. Cell based therapies have shown promise for repairing cartilage and bone; however, ... -
3D printed microchannel networks to direct vascularisation during endochondral bone repair
(2018)Bone tissue engineering strategies that recapitulate the developmental process of endochondral ossification offer a promising route to bone repair. Clinical translation of such endochondral tissue engineering strategies ... -
Adaptive Liquid Cooling Methods in Microchannel Heat Sinks
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)This work investigates the effect of implementing three varying cooling techniques for high heat flux electronics cooling. High heat fluxes are being experienced in data centres as the number of transistors per inch increases ... -
Altering the architecture of tissue engineered hypertrophic cartilaginous grafts facilitates vascularisation and accelerates mineralisation.
(2014)Cartilaginous tissues engineered using mesenchymal stem cells (MSCs) can be leveraged to generate bone in vivo by executing an endochondral program, leading to increased interest in the use of such hypertrophic grafts ... -
An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue
(2012)Inelastic phenomena such as softening and unrecoverable inelastic strains induced by loading have been observed experimentally in soft tissues such as arteries. These phenomena need to be accounted for in constitutive ... -
Apparent behaviour of charged and neutral materials with ellipsoidal fibre distributions and cross-validation of finite element implementations
(2012)Continuous fibre distribution models can be applied to a variety of biological tissues with both charged and neutral extracellular matrices. In particular, ellipsoidal models have been used to describe the complex material ... -
Applying thermal post-processing techniques to engineer the microstructure and mechanical performanceof selective-laser-melted Ti-6Al-4V ELI
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)As an additive manufacturing technology, selective laser melting (SLM) affords the creation of customisable parts at high resolutions to within the micron range. Among the materials being processed by SLM systems, the ... -
Biofabrication and bioprinting using cellular aggregates, microtissues and organoids for the engineering of musculoskeletal tissues
(2021)The modest clinical impact of musculoskeletal tissue engineering (TE) can be attributed, at least in part, to a failure to recapitulate the structure, composition and functional properties of the target tissue. This has ... -
Biofabrication of Prevascularised Hypertrophic Cartilage Microtissues for Bone Tissue Engineering
(2021)Bone tissue engineering (TE) has the potential to transform the treatment of challenging musculoskeletal pathologies. To date, clinical translation of many traditional TE strategies has been impaired by poor vascularisation ... -
Biomaterial based modulation of macrophage polarization: A review and suggested design principles
(2015)Macrophages have long been known for their phagocytic capabilities and immune defence; however, their role in healing is being increasingly recognized in recent years due to their ability to polarize into pro-inflammatory ... -
Bubble Impingement and the Mechanisms of Heat Transfer
(2014)Heat transfer augmentation resulting from the effects of two phase flow can play a significant role in convective cooling applications. To date, the interaction between a rising gas bubble impinging on a heated horizontal ... -
Cell-matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure
(2012)Both hydrostatic pressure (HP) and cell-matrix interactions have independently been shown to regulate the chondrogenic differentiation of mesenchymal stem cells (MSCs). The objective of this study was to test the hypothesis ... -
Characterization of extracellular matrix modified poly(¿-caprolactone) electrospun scaffolds with differing fiber orientations for corneal stroma regeneration
(2020)Alternatives to donor cornea transplantation based on tissue engineering are desirable to overcome the current severe donor tissue shortage. Many natural polymers have good biological properties but poor mechanical properties ... -
Chondrogenesis and integration of mesenchymal stem cells within an in vitro cartilage defect repair model
(2009)Integration of repair tissue is a key indicator of the long-term success of cell-based therapies for cartilage repair. The objective of this study was to compare the in vitro chondrogenic differentiation and integration ... -
Collagen fibre characterisation in arterial tissue under load using SALS
(2017)The collagen fibre architecture of arterial tissue is known to play a key role in its resultant mechanical behaviour, while maladaptive remodelling of this architecture may be linked to disease. Many of the techniques ... -
Combining BMP-6, TGF-β3 and hydrostatic pressure stimulation enhances the functional development of cartilage tissues engineered using human infrapatellar fat pad derived stem cells
(2013)The objective of this study was to identify a combination of growth factors that could be used with hydrostatic pressure (HP) stimulation to enhance the functional development of cartilaginous grafts engineered using human ... -
The Composition of Engineered Cartilage at the Time of Implantation Determines the Likelihood of Regenerating Tissue with a Normal Collagen Architecture.
(2013)The biomechanical functionality of articular cartilage is derived from both its biochemical composition and the architecture of the collagen network. Failure to replicate this normal Benninghoff architecture in regenerating ...