Browsing Mechanical, Manufacturing & Biomedical Eng by Sponsor "European Research Council (ERC)"
Now showing items 1-20 of 36
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3D Bioprinted Cartilaginous Templates as Developmentally Inspired Implants for Large Bone Defect Regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)Whilst bone possesses an inherent capacity for regeneration, defects above a critical size cannot heal on their own. Damaged or diseased bone can be treated using autografts or a range of different bone grafting biomaterials, ... -
3D bioprinting of cartilage-mimetic implants for biological joint resurfacing
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)A major challenge in the field of tissue engineering and regenerative medicine is the development of effective therapies for treating large cartilage or osteochondral defects and ultimately regenerating whole osteoarthritic ... -
3D Bioprinting of Developmentally Inspired Templates for Bone and Joint Regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)There is an urgent need to develop alternatives to synthetic joint prosthesis to promote the regeneration of diseased osteoarthritic joints. Cell based therapies have shown promise for repairing cartilage and bone; however, ... -
Biophysical Regulation of Stem Cell Osteogenic Lineage Commitment: A Role for the Cytoskeleton
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Osteoporosis is a debilitating disease characterised by weakened bone architecture due to increased resorption activity of osteoclasts and diminished bone deposition by mesenchymal stem cell (MSC) derived osteoblasts. ... -
Cell-matrix interactions regulate mesenchymal stem cell response to hydrostatic pressure
(2012)Both hydrostatic pressure (HP) and cell-matrix interactions have independently been shown to regulate the chondrogenic differentiation of mesenchymal stem cells (MSCs). The objective of this study was to test the hypothesis ... -
Collagen fibre characterisation in arterial tissue under load using SALS
(2017)The collagen fibre architecture of arterial tissue is known to play a key role in its resultant mechanical behaviour, while maladaptive remodelling of this architecture may be linked to disease. Many of the techniques ... -
Cyclic Hydrostatic Pressure Promotes A Stable Cartilage Phenotype And Enhances The Functional Development Of Cartilaginous Grafts Engineered Using Multipotent Stromal Cells Isolated From Bone Marrow And Infrapatellar Fat Pad.
(2014)The objective of this study was to investigate how joint specific biomechanical loading influences the functional development and phenotypic stability of cartilage grafts engineered in vitro using stem/progenitor cells ... -
Deciphering the Molecular Mechanisms of Stem Cell Mechanotransduction: A New Avenue for the Development of Therapeutics for Osteoporosis
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Osteoporosis is characterised by reduced bone density and weakened bone architecture leading to high fracture risk. The changes in bone result from an imbalance in the bone remodelling cycle whereby the rate of resorption ... -
Determination of two-dimensional space-time correlations in jet flows using simultaneous PIV and LDV measurements
(2010)The two-dimensional space-time turbulence statistics of free shear jet flows in the form of the two-point velocity correlation tensor are important for aeroacoustic noise source modelling based on the acoustic analogy ... -
Development and characterization of corneal substitutes from decellularized tissues
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)Diseases affecting the cornea can lead to vision impairment and ultimately to blindness. It is estimated that 45 million people worldwide suffer from corneal blindness. Rejection in high-risk patients and donor shortage ... -
The Development of a Novel 3D Bioprinting Strategy to Drive Vascularisation, and its Application for Bone Tissue Engineering
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)One of the major challenges facing the field of tissue engineering today is vascularisation. Without a system in place to circulate oxygen, nutrients and metabolites, the size of many tissue engineered constructs is ... -
Development of mechanobiomimetic strategies to drive stem cell behaviour for bone regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)There are a host of cases where clinical intervention must be taken to treat diseased or damaged bone, including severe fractures, defects, tumours requiring tissue removal, and debilitating diseases such as osteoporosis. ... -
Diffusion tensor imaging and arterial tissue: establishing the influence of arterial tissue microstructure on fractional anisotropy, mean diffusivity and tractography
(2021)In this study we investigated the potential of diffusion tensor imaging (DTI) for providing insight into microstructural changes in arterial tissue by exploring the influence that cell, collagen and elastin content have ... -
Expansion in the presence of FGF-2 enhances the functional development of cartilaginous tissues engineered using infrapatellar fat pad derived MSCs
(2012)MSCs from non-cartilaginous knee joint tissues such as the infrapatellar fat pad (IFP) and synovium possess significant chondrogenic potential and provide a readily available and clinically feasible source of chondroprogenitor ... -
Experimental Investigations of Coherence Based Noise Source Identification Techniques for Turbomachinery Applications - Classic and Novel Techniques (AIAA-2011-2830)
(2011)Coherence based noise source identi cation techniques utilise the ordinary linear coherence function between two signals to identify the contribution of one or more sources to the noise measured at a location of interest. ... -
Fundamental Insights into Arterial Remodelling; Strain-Mediated Degradation of Arterial Collagen
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Maladaptive remodelling of structurally significant collagen fibres in the arterial wall is believed to play a critical role in the development and progression of degenerative arterial disease. A greater understanding of ... -
Influence of Mechanical Environment on Limbal and Corneal Epithelial Cells
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Corneal blindness is the 4th leading cause of blindness and the most transplanted tissue worldwide. Severe donor shortages and immune rejection has led to research into alternative therapies for corneal transplantation. ...