Browsing Mechanical, Manufacturing & Biomedical Eng by Author "Ahearne, Mark"
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Combined influence of basal media and fibroblast growth factor on the expansion and differentiation capabilities of adipose-derived stem cells.
Ahearne, Mark; Lysaght, Joanne (2014)BACKGROUND: Interest in adipose-derived stem cells (ASCs) has increased in recent years due to their multi-linage differentiation capabilities. While much work has been done to optimize the differentiation media, few ... -
Designing Scaffolds for Corneal Regeneration
Ahearne, Mark (2020)Corneal blindness is one of the most common causes of vision loss worldwide, affecting millions of people. To treat these patients, researchers have been examining different approaches to engineer corneal scaffolds suitable ... -
The effect of prior long-term recellularization with keratocytes of decellularized porcine corneas implanted in a rabbit anterior lamellar keratoplasty model.
Ahearne, Mark (2021)Decellularized porcine corneal scaffolds are a potential alternative to human cornea for keratoplasty. Although clinical trials have reported promising results, there can be corneal haze or scar tissue. Here, we examined ... -
Fabrication and biocompatibility of electroconductive silk fibroin/pedot: Pss composites for corneal epithelial regeneration
Ahearne, Mark (2020)The aim of this study was to develop matrices that can support human corneal epithelial cells and innervation by incorporating a conducting polymer, poly(3,4-ethylenedioxythiophene) poly(styrene sulfonate) (PEDOT:PSS), ... -
Influence of micropatterned substrates on keratocyte phenotype
Ahearne, Mark (2020)Substrate topographic patterning is a powerful tool that can be used to manipulate cell shape and orientation. To gain a better understanding of the relationship between surface topography and keratocyte behavior, surface ... -
Mechanobiology of the corneal epithelium.
Ahearne, Mark (2018) -
Retinoic Acid Enhances the Differentiation of Adipose-Derived Stem Cells to Keratocytes In Vitro.
Ahearne, Mark (2017)Purpose: All-trans retinoic acid (RA) supplementation was investigated as a method of enhancing the differentiation of human adipose-derived stem cells (ASCs) to corneal keratocytes in vitro, in combination with a chemically ... -
Significance of Crosslinking Approaches in the Development of Next Generation Hydrogels for Corneal Tissue Engineering.
Ahearne, Mark (2021)Medical conditions such as trachoma, keratoconus and Fuchs endothelial dystrophy can damage the cornea, leading to visual deterioration and blindness and necessitating a cornea transplant. Due to the shortage of donor ...