Synthesis of biomedical relevant porphyrins
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2007Access:
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Yasser Mohamed Shaker Abdelrahman Atta, 'Synthesis of biomedical relevant porphyrins', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2007, pp 189Download Item:
Abstract:
The research carried out in the present study focuses mainly on the synthesis of functionalized, unsymmetrically substituted porphyrins for potential applications in photodynamic therapy. Chapter 1 introduces the different classes of porphyrins and describes the most significant general methodologies employed for the synthesis of various classes of meso-substituted porphyrins.
The symmetric porphyrin starting materials (A2-porphyrins) are easily prepared by simple condensation reactions of dipyrromethane and suitable aldehydes. These porphyrins are then functionalized by a nucleophilic aromatic substitution reaction (SnAr) with a wide variety of aliphatic, aromatic and functionalized organolithium reagents.
Chapter 2 is concerned with an efficient synthesis of novel A2BC-porphyrins bearing highly reactive centers in substituents at the meso positions using corresponding functionalized organolithium reagents via two-step reactions.
Advisor:
Senge, MathiasQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of ChemistryNote:
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Chemistry, Ph.D., Ph.D. Trinity College DublinMetadata
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