Amyotrophic Lateral Sclerosis (ALS) is a terminal neuro-degenerative disorder of adults, typically having rapid progression and involving both motor and cognitive function. ALS exhibits considerable heterogeneity of both ...

Novelty: Because the vast majority of ALS imaging studies focus on evaluating motor pathology, the focus and novelty of this work is the nuanced characterisation of extra-motor involvement in a genetically stratified cohort ...