Browsing Trinity College Dublin Theses & Dissertations by Subject "M.D. Trinity College Dublin"
Now showing items 1-20 of 62
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A surgical delivery system for targeted cancer gene therapy : the potential therapeutic role of genetically modified microvascular free flaps in the management of primary tumours
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Gene therapy has generated interest for the treatment of soft tissue malignancies. It offers the theoretical promise of delivering cytotoxic, immunomodulatory, or anti- angiogenic genes to produce proteins targeting tumour ... -
Acidosis at birth in term infants and early neurophysiological and cardiovascular changes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Paediatrics, 2005)This thesis was mounted to evaluate and quantify the role of umbilical cord pH measurements in relation to the baby’s clinical condition, electroencephalographic pattern, heart rate variability and analysis of sucking ... -
An in vivo study of utricular hair cell degeneration and regeneration following animoglycoside induced damage of the mammalian inner ear
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)The anatomy of the mammalian ear is similar between the different subspecies. This applies to the structure of the utricle in humans and in guinea pigs. Hence the choice of the guinea pig utricle allows any findings ... -
An investigation of risk factors for fracture in patients with osteoporosis and osteopaenia using biomechanical, biochemical and radiological assessments
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Osteoporosis is defined as a skeletal disorder characterised by compromised bone strength resulting in an increased risk for fracture. Hip fractures are the most common osteoporotic fracture in older adults and occur due ... -
Bereavement and people with intellectual disabilities
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2007)For most people, the loss of a loved one is a tragedy unequalled by any other. It affects every family and raises policy and logistic issues for the health and social service agencies of every community. Currently, people ... -
Checking the weight of children in general practice
(Trinity College (Dublin, Ireland). Department of Public Health and Primary Care, 2015)Childhood overweight is a serious health concern. Checking the weight of the child can be done in the primary care setting, where GPs have the opportunity to check the weight of children attending for routine care.It is ... -
Children and adolescents with cystic fibrosis attending the three specialist Dublin respiratory units : clinical, metabolic, quality of life and genetic aspects
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Paediatrics, 2008)Patients with cystic fibrosis related diabetes (CFRD) have a six-fold increase in morbidity and mortality (Moran, 2002a). CFRD is usually asymptomatic and can remain undetected for up to four years prior to diagnosis. ... -
Children born small for gestational age (SGA) : growth and clinical assessment at age 4 to 6 years and treatment with recombinant growth hormone in children born SGA without catch up growth
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Paediatrics, 2009)Small for gestational age (SGA) is a descriptive term used to describe a baby who is bom smaller than expected for its gender and gestation. By international consensus the current definition is a birth weight ≥2 standard ... -
Clinicopathological and inflammatory prognostic factors in non-small cell lung cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Lung cancer is the most common cause of cancer death worldwide. Despite improvements in diagnosis and treatments, the overall prognosis for patients with lung cancer remains poor and novel therapeutic approaches are required. ... -
Colorectal cancer screening
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Colorectal cancer is a major public health burden and is the most common cause of mortality from cancer in Europe. Over the last two decades robust evidence from randomised clinical trials and case-control series have ... -
Continuous glucose monitoring in a cohort of prepubertal children with Type 1 diabetes mellitus : a comparison of glycaemic outcomes to clinical and biochemical markers of diabetes control
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Paediatrics, 2009)In type 1 diabetes, monitoring of glycaemic status is considered a cornerstone of diabetes care and vital in the prevention of diabetes complications. Intermittent daily self monitoring of blood glucose levels provides a ... -
Cutaneous changes in renal transplant recipients - is there a relationship between benign and malignant disease?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Renal transplant recipients are at an increased risk of many cutaneous diseases. The increased incidence of cutaneous malignancy is well recognised. Cutaneous infections and iatrogenic effects of immunosuppressive medications ... -
Defining inherited haematological disease within the Irish traveller population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2006)The Traveller Community in Ireland constitutes a minority of nomadic or semi-nomadic people, sharing a common Irish ancestry. The Traveller Health Study showed that in 1987, Travellers were only reaching the life expectancy ... -
Developing a national reference range for paediatric bone density
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Paediatrics, 2014)This study aimed to acquire normative dual energy x-ray absorptiometry (DXA] bone density data for Irish Caucasian children. A total of 162 healthy Irish Caucasian children (84 male, 78 female) aged between six and 16 years ... -
Exposure to reduced oxygenation following radiation exposure enhances the survival of prostate cancer cells in vitro: implications for radiation therapy delivery
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2010)Introduction: Hypoxia is a common feature of prostate tumours; hypoxic cells are more radioresistance compared to oxygenated cells. Hypoxic radioresistance has also been shown to be related to the duration of hypoxia prior ... -
Factors modulating TLR2, TLR4 and HBD2 expression in respiratory epithelium in COPD
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)The innate immune response of the respiratory epithelium, employing mechanisms of germ-line encoded, genetically conserved pattern recognition to “non-self’ organisms, is an important component of host defence against ... -
Gastro-oesophageal reflux disease : studies in physiology and innovations in surgical management
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2007)The work detailed in this thesis combined studies in surgical audit with assessment of outcomes relating to dysmotility, evaluated an innovative approach to quality assurance in surgery, explored new understandings of ... -
Intestinal microsomal triglyceride transfer protein, promoter region polymorphisms and postprandial lipoproteins in Type 2 Diabetes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)Microsomal triglyceride transfer protein is an ancient lipid transfer protein responsible for the assembly of chylomicrons in the intestine and very low density lipoproteins in the liver. Common MTP gene promoter region ... -
Investigating the role of constitutively active truncated androgen receptor splice variants in prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine, 2012)The androgen receptor (AR) is fundamental for the growth and survival of normal and malignant prostate cells. Therefore, androgen deprivation therapy remains the first‐line treatment for disseminated disease, however, ... -
Investigation of ABO blood group expresser phenotype
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)The aims of this project were to study the variability of the ABO blood group expression on human platelets and to explore the underlying molecular mechanisms. 541 Irish blood donors were studied. The recently described ...