Browsing Trinity College Dublin Theses & Dissertations by Sponsor "Health Research Board (HRB)"
Now showing items 1-20 of 48
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Adaptive immune response in human Staphylococcus aureus bloodstream infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Staphylococcus aureus bloodstream infection is a common and life-threatening condition. Treatment outcomes are poor, suboptimal clinical management is common, antimicrobial resistance continues to emerge, and there are few ... -
Characterising Macrophage Immunometabolism in Mycobacterium tuberculosis and HIV Co-Infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction Tuberculosis (TB) and HIV are leading infection-related causes of global mortality and result in an enormous amount of suffering and economic loss. Available TB treatment strategies are inadequate, and vaccination ... -
Deep phenotyping through biomarker profiling of frontotemporal dementia (FTD) with and without co-morbid motor neuron degeneration: A multidimensional approach
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)PhD Thesis abstract: Trinity College Dublin Title: Deep Phenotyping Through biomarker Profiling of Frontotemporal Dementia (FTD) With and Without Co-morbid Motor Neuron Degeneration: A Multidimensional Approach Authors: ... -
Determinants of Physical Activity Engagement and Physical Activity Intervention Adherence in Individuals with Mild Cognitive Impairment: A Mixed Methods Study
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2022)The overarching aim of this thesis was to to identify the determinants of PA engagement and PA intervention adherence in individuals with MCI to expand on this under-researched topic and better inform PA promotion and ... -
Development of a core set of clinical care provision indicators for non-specialist palliative care in hospitals
(Trinity College Dublin. School of Nursing & Midwifery. Discipline of Nursing, 2020)Background: Ageing populations with associated chronic illnesses and multi-morbidity will lead to a rapidly escalating need for all levels of palliative care provision. This will place significant pressures on health systems ... -
ECHO: the epidemiology of HPV infection in oropharyngeal, oral cavity, and laryngeal cancer in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2019)Human Papillomavirus (HPV) infection has been identified as a significant etiological agent in the development of head and neck squamous cell carcinoma (HNSCC). There is mounting evidence from North America and Europe to ... -
The Effects of Acute and Chronic Exercise on Brain Derived Neurotrophic Factor and Cognitive Performance in Mild Cognitive Impairment
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2019)Introduction: Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that supports neural survival, growth and synaptic plasticity and is upregulated through exercise. While the exact neuronal mechanisms underlying the ... -
Effects of high -intensity interval vs moderate-intensity continous training on the time course adapations in cardiovascular fitness and oxygen uptake kinetics in type 2 diabetes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)Individuals with type 2 diabetes mellitus (T2DM) present with significant impairments in the dynamic and peak responses of pulmonary oxygen uptake (V̇O2) during exercise. Both low-volume high-intensity interval training ... -
Engagement in Daily Life Activities of Adults Ageing with an Intellectual Disability
(Trinity College Dublin. School of Nursing & Midwifery. Discipline of Nursing, 2018)Background: Occupational therapists view engagement in meaningful activities to be a key determinant of health and well-being. As the population of people ageing with an intellectual disability (ID) continues to grow, ... -
The Environmental Epidemiology of Amyotrophic Lateral Sclerosis in Europe
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Amyotrophic Lateral Sclerosis (ALS) is a terminal neuro-degenerative disorder of adults, typically having rapid progression and involving both motor and cognitive function. ALS exhibits considerable heterogeneity of both ... -
An Ethnography of Independent Midwifery in Ireland
(Trinity College Dublin, 2009)Homebirths in Ireland -
Evaluation of diagnostic and treatment strategies for the management of Helicobacter pylori infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Helicobacter pylori infection is responsible for chronic gastritis and the development of gastrointestinal disorders such as gastric or duodenal ulcers, gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) ... -
Examining the breadth and burden of chronic kidney disease in community-dwelling older adults
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2017)Introduction: Chronic kidney disease (CKD), characterised by reductions in glomerular filtration rate (GFR), is associated with premature mortality and end stage kidney disease. Older adults have the highest prevalence of ... -
Examining the effects of cognitive training on levels of executive function in adults with down syndrome: A feasibility study
(Trinity College Dublin. School of Nursing & Midwifery. Discipline of Nursing, 2017)Introduction Individuals with Down syndrome are at much greater risk of developing AD, and one of the early clinical symptoms of AD is executive dysfunction. In the general population, cognitive training has shown some ... -
Exercise Therapy as a Treatment for Chronic Liver Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2020)Hepatitis C (HCV) and Non-Alcoholic Fatty Liver Disease (NAFLD) are among the leading causes of chronic inflammatory liver disease. HCV and NAFLD present with numerous hepatic and extrahepatic features which culminates in ... -
Exploration of a novel class of HO-1 inducers as potential therapeutics for inflammatory disease
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Autoimmune and inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, and inflammatory bowel disease (IBD) are characterised by excessive and uncontrolled inflammation. Most of these ... -
Facilitating readiness for advance care planning in Ireland: Informing the design of an innovative intervention for middle aged and older people in the community
Background: Advance care planning (ACP) is a process aiming to elicit, communicate, and document future care wishes, providing mechanisms through which individual preferences can be supported. Poor and fragmented ... -
Harnessing the therapeutic properties of the Heme Oxygenase system
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2018)The stress response enzyme, Heme Oxygenase 1 (HO-1), has been identified as an important immunomodulator which is highly upregulated in response to cellular stress and inflammation. HO-1 catalyses the conversion of free ... -
How can health systems make healthcare more accessible for populations experiencing homelessness? A realist and policy analysis
(Trinity College Dublin. School of Medicine. Discipline of Public Health & Primary Care, 2022)Problem Populations experiencing long-term homelessness and complex needs face difficulties accessing healthcare. Prior research has predominantly focused on the individual characteristics that contribute to those ... -
HPV Primary Screening Pilot Study: molecular testing of potential triage strategies for HPV-positive women.
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2020)Cytological based screening programmes are being phased out in favour of HPV-based screening both in Ireland and internationally. Infection with HPV is the primary aetiological agent in the development of cervical cancer. ...