Browsing Pharmaceutical Chemistry by Author "Greene, Thomas F."
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The design, synthesis, and evaluation of the Azetidin-2-one ring as a scaffold for novel combretastatin A4 analogues
Greene, Thomas F. (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)Combretastatin A-4 (CA4) is a natural product first isolated from the Combretum caffrum South African willow tree by Pettit and co-workers. CA4 has proved to be a potent antimitotic agent, with a mechanism of action ...