Browsing RSS Feeds by Sponsor "Medical Research Council"
Now showing items 1-16 of 16
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ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.
(American Society for Biochemistry and Molecular Biology, 2005)Rac and its downstream effectors p21-activated kinase (PAK) family kinases regulate actin dynamics within growth cones to control neurite outgrowth during development. The activity of Rac is stimulated by guanine ... -
The Appearance of escape variants in vivo does not account for the failure of recombinant envelope vaccines to protect against simian immunodeficiency virus
(Society for General Microbiology, 1999)The presence or evolution of immune escape variants has been proposed to account for the failure of recombinant envelope vaccines to protect macaques against challenge with simian immunodeficiency virus (SIVmac). To address ... -
Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin.
(American Association for Clinical Chemistry, 2007)Background: Impaired vitamin B12 function and decreased vitamin B12 status have been associated with neurological and cognitive impairment. Current assays analyze total vitamin B12 concentration, only a small percentage ... -
A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
(PLoS, 2007)The Toll-like receptor 4 (TLR4) is a class I transmembrane receptor expressed on the surface of immune system cells. TLR4 is activated by exposure to lipopolysaccharides derived from the outer membrane of Gram negative ... -
Dissociable mechanisms of cognitive control in human prefrontal cortex
(The American Physiological Society, 2007)Intelligent behavior depends on the ability to suppress inappropriate actions and resolve interference between competing responses. Recent clinical and neuroimaging evidence has demonstrated the involvement of prefrontal, ... -
Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention.
(Elsevier, 2007)Attention deficit hyperactivity disorder (ADHD) and autism are two neurodevelopmental disorders associated with prominent executive dysfunction, which may be underpinned by disruption within fronto-striatal and fronto-parietal ... -
Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a develomental perspective
(The Royal College of Psychiatrists, 2007)Attention-deficit hyperactivity disorder (ADHD) varies in its clinical presentation and course. Susceptibility gene variants for ADHD and associated antisocial behaviour are being identified with emerging evidence of ... -
Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.
(The Society for Neuroscience, 2003)Here we characterize a novel neuronal kinase, cyclin-dependent kinase 5 (cdk5)/p35-regulated kinase (cprk). Cprk is a member of a previously undescribed family of kinases that are predicted to contain two N-terminal ... -
Resolution of inflammation: state of the art, definitions and terms
(The Federation of American Societies for Experimental Biology., 2006)A recent focus meeting on Controlling Acute Inflammation was held in London, April 27-28, 2006, organized by D.W. Gilroy and S.D. Brain for the British Pharmacology Society. We concluded at the meeting that a consensus ... -
SIGN-R1 contributes to protection against lethal pneumococcal infection in mice
(Rockefeller University Press, 2004)Rapid clearance of pathogens is essential for successful control of pyogenic bacterial infection. Previous experiments have shown that antibody to specific intracellular adhesion molecule-grabbing nonintegrin (SIGN)-R1 ... -
Specificity and plasticity of thalamocortical connections in Sema6A mutant mice.
(2009)The establishment of connectivity between specific thalamic nuclei and cortical areas involves a dynamic interplay between the guidance of thalamocortical axons and the elaboration of cortical areas in response to appropriate ... -
Transplantation of syngeneic schwann cells to the retina of the rhodopsin knockout (Rho-/-) mouse
(The Association for Research in Vision and Ophthalmology, Inc., 2003)PURPOSE: To determine whether subretinal Schwann cell transplantation can prolong the survival of photoreceptors in the rhodopsin knockout (rho(-/-)) mouse. METHODS: Schwann cells were prepared from postnatal day (PN) 5 ... -
Understanding cumulative risk
(2010)The authors investigated the relationship between reasoners' understanding of subjunctive conditionals (e.g., if p had happened, then q would have happened) and the inferences they were prepared to endorse. Reasoners who ... -
X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.
(2009)Increased production and deposition of amyloid ?-protein (A?) are believed to be key pathogenic events in Alzheimer?s disease. As such, routes for lowering cerebral A? levels represent potential therapeutic targets for ...