Browsing Microbiology by Sponsor "Science Foundation Ireland (SFI)"
Now showing items 1-20 of 56
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Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus
(2014)Staphylococcus aureus is an important opportunistic pathogen and persistently colonizes about 20% of the human population. Its surface is 'decorated' with proteins that are covalently anchored to the cell wall peptidoglycan. ... -
Antimitotic herbicides bind to an unidentifed site on malarial parasite tubulin and block development of liver-stage Plasmodium parasites.
(2013)Malarial parasites are exquisitely susceptible to a number of microtubule inhibitors but most of these compounds also affect human microtubules. Herbicides of the dinitroaniline and phosphorothioamidate classes however ... -
Broad scale redistribution of mRNA abundance and transcriptional machinery in response to growth rate in Salmonella enterica serovar Typhimurium
(2017)We have investigated the connection between the four-dimensional architecture of the bacterial nucleoid and the organism's global gene expression programme. By localizing the transcription machinery and the transcriptional ... -
Consequences of producing DNA gyrase from a synthetic gyrBA operon in Salmonella enterica serovar Typhimurium
(2021)DNA gyrase is an essential type II topoisomerase that is composed of two subunits, GyrA and GyrB and has an A 2 B 2 structure. Although both subunits are required in equal proportions to form DNA gyrase, the gyrA and gyrB ... -
Control of virulence gene transcription by indirect readout in Vibrio cholerae and Salmonella enterica serovar Typhimurium
(2017)Indirect readout mechanisms of transcription control rely on the recognition of DNA shape by transcription factors (TFs). TFs may also employ a direct readout mechanism that involves the reading of the base sequence in the ... -
Design and evaluation of antimalarial peptides derived from prediction of short linear motifs in proteins related to erythrocyte invasion
(2015)The purpose of this study was to investigate the blood stage of the malaria causing parasite, Plasmodium falciparum, to predict potential protein interactions between the parasite merozoite and the host erythrocyte and ... -
DNA supercoiling and transcription: a two-way street
(2019)Background : The processes of DNA supercoiling and transcription are interdependent because the movement of a transcription elongation complex simultaneously induces under- and over winding of the DNA duplex and because ... -
Fermentation innovation through complex hybridization of wild and domesticated yeasts
(2019)The most common fermented beverage, lager beer, is produced by interspecies hybrids of the brewing yeast Saccharomyces cerevisiae and its wild relative S. eubayanus. Lager-brewing yeasts are not the only example of hybrid ... -
A fundamental regulatory mechanism operating through OmpR and DNA topology controls expression of Salmonella pathogenicity islands SPI-1 and SPI-2
(2012)DNA topology has fundamental control over the ability of transcription factors to access their target DNA sites at gene promoters. However, the influence of DNA topology on protein–DNA and protein–protein interactions is ...