Browsing Microbiology by Author "MCLOUGHLIN, RACHEL"
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Nasal Colonisation by Staphylococcus aureus Depends upon Clumping Factor B Binding to the Squamous Epithelial Cell Envelope Protein Loricrin.
GEOGHEGAN, JOAN; MCLOUGHLIN, RACHEL; FOSTER, TIMOTHY (2012)Staphylococcus aureus asymptomatically colonises the anterior nares, but the host and bacterial factors that facilitate colonisation remain incompletely understood. The S. aureus surface protein ClfB has been shown to ... -
Targeted nasal vaccination provides antibody independent protection against Staphylococcus aureus.
MCLOUGHLIN, RACHEL; LAVELLE, EDWARD; GEOGHEGAN, JOAN; FOSTER, TIMOTHY (2014)Despite showing promise in preclinical models, anti–Staphylococcus aureus vaccines have failed in clinical trials. To date, approaches have focused on neutralizing/opsonizing antibodies; however, vaccines exclusively ...