dc.contributor.author | HEALY, ANNE | en |
dc.contributor.author | CORRIGAN, OWEN | en |
dc.contributor.author | TAJBER, LIDIA | en |
dc.contributor.author | GROSSJOHANN, CHRISTINE | en |
dc.date.accessioned | 2012-01-12T16:16:43Z | |
dc.date.available | 2012-01-12T16:16:43Z | |
dc.date.issued | 2012 | en |
dc.date.submitted | 2012 | en |
dc.identifier.citation | Grossjohann C, Eccles KS, Maguire AR, Lawrence SE, Tajber L, Corrigan OI, Healy AM, Characterisation, solubility and intrinsic dissolution behaviour of benzamide:dibenzyl sulfoxide cocrystal, International Journal of Pharmaceutics, 422, 1-2, 2012, 24-32 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/61638 | |
dc.description | PUBLISHED | en |
dc.description.abstract | This study examined the 1:1 cocrystal benzamide:dibenzyl sulfoxide, comprising the poorly water soluble dibenzyl sulfoxide (DBSO) and the more soluble benzamide (BA), to establish if this cocrystal shows advantages in terms of solubility and dissolution in comparison to its pure components and to a physical mixture. Solubility studies were performed by measuring DBSO solubility as a function of BA concentration, and a ternary phase diagram was constructed. Dissolution was examined through intrinsic dissolution studies. Solid state characterisation was carried out by powder X-ray diffraction (PXRD), energy-dispersive X-ray diffraction (EDX), infra-red spectroscopy (ATR-FTIR) and thermal analysis. DBSO solubility was increased by means of complexation with BA. For the cocrystal, the solubility of both components was decreased in comparison to pure components. The cocrystal was identified as metastable and incongruently saturating. Dissolution studies revealed that dissolution of DBSO from the cocrystal was not enhanced in comparison to the pure compound or a physical mix, while BA release was retarded and followed square root of time kinetics. At the disk surface a layer of DBSO was found. The extent of complexation in solution can change the stability of the complex substantially. Incongruent solubility and dissolution behaviour of a cocrystal can result in no enhancement in the dissolution of the less soluble component and retardation of release of the more soluble component. | en |
dc.description.sponsorship | The authors gratefully acknowledge J.-R. Authelin and P. Billot from Sanofi Aventis for their
advice and help concerning ternary phase diagram and N. Maguire from the Chemistry
Department in University College Cork for developing the HPLC method. This publication
has emanated from research conducted with the financial support of Science Foundation Ireland, under grant numbers 07/SRC/B1158 (Solid State Pharmaceutical Cluster) and
08/RFP/MTR1664. | en |
dc.format.extent | 24-32 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | International Journal of Pharmaceutics | en |
dc.relation.ispartofseries | 422 | en |
dc.relation.ispartofseries | 1-2 | en |
dc.rights | Y | en |
dc.subject | Pharmacology | en |
dc.subject | Intrinsic dissolution | en |
dc.subject | cocrystals | en |
dc.subject | solubility | en |
dc.title | Characterisation, solubility and intrinsic dissolution behaviour of benzamide:dibenzyl sulfoxide cocrystal | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/healyam | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/ltajber | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/ocorrign | en |
dc.identifier.rssinternalid | 75373 | en |
dc.identifier.doi | 10.1016/j.ijpharm.2011.10.016 | en |
dc.identifier.rssuri | http://dx.doi.org/10.1016/j.ijpharm.2011.10.016 | en |
dc.identifier.orcid_id | 0000-0001-5093-9786 | en |
dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |
dc.contributor.sponsorGrantNumber | 08/RFP/MTR1664 | en |
dc.contributor.sponsor | Science Foundation Ireland (SFI) | en |
dc.contributor.sponsorGrantNumber | 07/SRC/B1158 | en |