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dc.contributor.authorCOLEMAN, DAVIDen
dc.contributor.authorSULLIVAN, DEREKen
dc.contributor.authorMORAN, GARYen
dc.date.accessioned2011-09-16T10:05:27Z
dc.date.available2011-09-16T10:05:27Z
dc.date.issued2012en
dc.date.submitted2012en
dc.identifier.citationMORAN, GP, COLEMAN DC, SULLIVAN DJ, CANDIDA ALBICANS VERSUS CANDIDA DUBLINIENSIS: WHY IS C. ALBICANS MORE PATHOGENIC?, INTERNATIONAL JOURNAL OF MICROBIOLOGY, 2012, 2012, 17: e205921en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/59496
dc.descriptionPUBLISHEDen
dc.description4th Septemebr; Epub ahead of printen
dc.description.abstractCandida albicans and Candida dubliniensis are highly related pathogenic yeast species. However, C. albicans is far more prevalent in human infection and has been shown to be more pathogenic in a wide range of infection models. Comparison of the genomes of the two species has revealed that they are very similar although there are some significant differences, largely due to the expansion of virulence-related gene families (e.g., ALS and SAP) in C. albicans, and increased levels of pseudogenisation in C. dubliniensis. Comparative global gene expression analyses have also been used to investigate differences in the ability of the two species to tolerate environmental stress and to produce hyphae, two traits that are likely to play a role in the lower virulence of C. dubliniensis. Taken together, these data suggest that C. dubliniensis is in the process of undergoing reductive evolution and may have become adapted for growth in a specialized anatomic niche.en
dc.format.extent17: e205921en
dc.language.isoenen
dc.relation.ispartofseriesINTERNATIONAL JOURNAL OF MICROBIOLOGYen
dc.relation.ispartofseries2012en
dc.rightsYen
dc.subjectDental Scienceen
dc.subjectCandida dubliniensisen
dc.titleCANDIDA ALBICANS VERSUS CANDIDA DUBLINIENSIS: WHY IS C. ALBICANS MORE PATHOGENIC?en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/dcolemanen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/gmoranen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/djsullvnen
dc.identifier.rssinternalid74895en
dc.subject.TCDThemeGenes & Societyen
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.rssurihttp://dx.doi.org/10.1155/2012/205921en
dc.identifier.orcid_id0000-0003-1797-2888en


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