RSS 1.0School of Dental Sciences
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Global Transcriptome Sequencing Identifies Chlamydospore Specific Markers in Candida albicans and Candida dubliniensis.
(2013)Candida albicans and Candida dubliniensis are pathogenic fungi that are highly related but differ in virulence and in some phenotypic traits. During in vitro growth on certain nutrient-poor media, C. albicans and C. ... -
Emergence of Sequence Type 779 Methicillin-Resistant Staphylococcus aureus (MRSA) Harboring a Novel Pseudo Staphylococcal Cassette Chromosome mec (SCCmec)-SCC-SCCCRISPR Composite Element in Irish Hospitals.
(2013)Methicillin-resistant Staphylococcus aureus (MRSA) has been a major cause of nosocomial infection in Irish hospitals for 4 decades, and replacement of predominant MRSA clones has occurred several times. An MRSA isolate ... -
DETECTION OF mecC-POSITIVE Staphylococcus aureus (CC130-MRSA-XI) IN DISEASED EUROPEAN HEDGEHOGS (Erinaceus europaeus) IN SWEDEN
(2013)Recently, a novel mec gene conferring beta-lactam resistance in Staphylococcus aureus has been discovered. This gene, mecC, is situated on a SCCmec XI element that has to date been identified in clonal complexes 49, 130, ... -
Reported difficulty tooth and denture cleaning among an ageing population with intellectual disabilities in Ireland
(2014)Aims and objectives: This paper aims to describe reported difficulty and frequency in carrying out oral hygiene practices among an ageing population with intellectual disabilities in Ireland; Methods: This cross-sectional ... -
An in vivo comparison of bacterial microleakage in two dental implant systems: identification of a pathogenic reservoir in dental implants
(2014)Objectives. The aim of this study was to compare internal bacterial colonization in two implant systems, one screw root form (SRF) with an external hexagon connection and one plateau root form (PRF) with a Morse taper ... -
DIFFERENTIAL REGULATION OF THE TRANSCRIPTIONAL REPRESSOR NRG1 ACCOUNTS FOR ALTERED HOST CELL INTERACTIONS IN CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS
(Blackwell Publishing, 2007-09)Candida dubliniensis is genetically closely related to C. albicans, but causes fewer infections in humans and exhibits reduced virulence and filamentation in animal models of infection. We investigated the role of the C. ... -
Triclosan antagonises fluconazole activity against Candida albicans
(2012)Triclosan is a broad-spectrum antimicrobial compound commonly used in oral hygiene products. Investigation of its activity against Candida albicans showed that triclosan was fungicidal at concentrations of 16 mg/L. However, ... -
Transcript profiling reveals rewiring of iron assimilation gene expression in Candida albicans and C. dubliniensis
(2012)Hyphal growth is repressed in Candida albicans and C. dubliniensis by the transcription factor Nrg1. Transcript profiling of a C. dubliniensis NRG1 mutant identified a common group of 28 NRG1 repressed genes in both species, ... -
Triclosan antagonises fluconazole activity against Candida albicans
(International Association for Dental Research (IADR), 2011-10-04)Triclosan is a broad-spectrum antimicrobial compound commonly used in oral hygiene products. Investigation of its activity against Candida albicans showed that triclosan was fungicidal at concentrations of 16 mg/L. However, ... -
AIR AND SURFACE CONTAMINATION PATTERNS OF METHICILLIN-RESISTANT Staphylococcus aureus ON EIGHT ACUTE HOSPITAL WARDS
(2014-03)BACKGROUND. Methicillin-resistant Staphylococcus aureus (MRSA) can be recovered from hospital air and from environmental surfaces. This poses a potential risk of transmission to patients. OBJECTIVE. To investigate ... -
Understanding head and neck cancers
(Irish Dental Association, 2013) -
STAPHYLOCOCCAL CASSETTE CHROSOMOME MEC: RECENT ADVANCES AND NEW INSIGHTS
(2013)Staphylococcal cassette chromosome (SCC) elements are complex mobile genetic elements that often carry antimicrobial resistance and in some cases virulence-associated genes. In addition to SCCmec, which harbours the ... -
GENOTYPING Candida albicans FROM CANDIDA LEUKOPLAKIA AND NON-CANDIDA LEUKOPLAKIA SHOWS NO ENRICHMENT OF MULTILOCUS SEQUENCE TYPING CLADES BUT ENRICHMENT OF ABC GENOTYPE C IN CANDIDA LEUKOPLAKIA
(2013)Oral leukoplakias are histopathologically-diagnosed as Candida leukoplakia or non-Candida leukoplakia by the presence or absence of hyphae in the superficial epithelium. Candida leukoplakia lesions have significantly ... -
EXTENSIVE GENETIC DIVERSITY IDENTIFIED AMONG SPORADIC METHICILLIN-RESISTANT Staphylococcus aureus ISOLATES RECOVERED IN IRISH HOSPITALS BETWEEN 2000-2012
(2014)Clonal replacement of predominant nosocomial methicillin-resistant Staphylococcus aureus (MRSA) strains has occurred several times in Ireland during the last four decades. However, little is known about sporadically-occurring ... -
MOLECULAR EPIDEMIOLOGY. PHYLOGENY AND EVOLUTION OF Candida albicans
(2014)A small number of Candida species form part of the normal microbial flora of mucosal surfaces in humans and may give rise to opportunistic infections when host defences are impaired. Candida albicans is by far the most ... -
PANTON-VALENTINE LEUKOCIDIN-POSITIVE STAPHYLOCOCCUS AUREUS IN IRELAND 2002-2011: TWENTY-ONE CLONES, FREQUENT IMPORTATION OF CLONES, TEMPORAL SHIFTS OF PREDOMINANT METHICILLIN-RESISTANT S. AUREUS AND INCREASING MULTIRESISTANCE
(2014)There has been a worldwide increase in community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA) infections. CA-MRSA isolates commonly produce the Panton-Valentine leukocidin toxin encoded by the pvl ... -
COMPARATIVE ADHERENCE OF CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS TO HUMAN BUCCAL EPITHELIAL CELLS AND EXTRACELLULAR MATRIX PROTEINS
(2014)Candida albicans and Candida dubliniensis are very closely related pathogenic yeast species. Despite their close relationship, the former is a far more successful coloniser and pathogen of humans. The purpose of the current ... -
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.
(2008)Abstract: Lung cancer is the most common cause of cancer death worldwide, with over one million cases annually(1). To identify genetic factors that modify disease risk, we conducted a genome- wide association study by ... -
Using the International Classification of Functioning, Disability and Health (ICF) to Describe Children Referred to Special Care or Paediatric Dental Services.
(2013)Children in dentistry are traditionally described in terms of medical diagnosis and prevalence of oral disease. This approach gives little information regarding a child's capacity to maintain oral health or regarding the ... -
ENRICHMENT OF MULTILOCUS SEQUENCE TYPING CLADE 1 WITH ORAL CANDIDA ALBICANS ISOLATES IN PATIENTS WITH UNTREATED PERIODONTITIS
(2012)This study investigated the prevalence and cell density of Candida species in periodontal pockets, healthy subgingival sites and in oral rinses of patients with untreated periodontitis. Twenty-one periodontitis patients ...