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DIFFERENTIAL REGULATION OF THE TRANSCRIPTIONAL REPRESSOR NRG1 ACCOUNTS FOR ALTERED HOST CELL INTERACTIONS IN CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS
(Blackwell Publishing, 2007-09)Candida dubliniensis is genetically closely related to C. albicans, but causes fewer infections in humans and exhibits reduced virulence and filamentation in animal models of infection. We investigated the role of the C. ... -
Triclosan antagonises fluconazole activity against Candida albicans
(2012)Triclosan is a broad-spectrum antimicrobial compound commonly used in oral hygiene products. Investigation of its activity against Candida albicans showed that triclosan was fungicidal at concentrations of 16 mg/L. However, ... -
Transcript profiling reveals rewiring of iron assimilation gene expression in Candida albicans and C. dubliniensis
(2012)Hyphal growth is repressed in Candida albicans and C. dubliniensis by the transcription factor Nrg1. Transcript profiling of a C. dubliniensis NRG1 mutant identified a common group of 28 NRG1 repressed genes in both species, ... -
Triclosan antagonises fluconazole activity against Candida albicans
(International Association for Dental Research (IADR), 2011-10-04)Triclosan is a broad-spectrum antimicrobial compound commonly used in oral hygiene products. Investigation of its activity against Candida albicans showed that triclosan was fungicidal at concentrations of 16 mg/L. However, ... -
AIR AND SURFACE CONTAMINATION PATTERNS OF METHICILLIN-RESISTANT Staphylococcus aureus ON EIGHT ACUTE HOSPITAL WARDS
(2014-03)BACKGROUND. Methicillin-resistant Staphylococcus aureus (MRSA) can be recovered from hospital air and from environmental surfaces. This poses a potential risk of transmission to patients. OBJECTIVE. To investigate ... -
Understanding head and neck cancers
(Irish Dental Association, 2013) -
STAPHYLOCOCCAL CASSETTE CHROSOMOME MEC: RECENT ADVANCES AND NEW INSIGHTS
(2013)Staphylococcal cassette chromosome (SCC) elements are complex mobile genetic elements that often carry antimicrobial resistance and in some cases virulence-associated genes. In addition to SCCmec, which harbours the ... -
GENOTYPING Candida albicans FROM CANDIDA LEUKOPLAKIA AND NON-CANDIDA LEUKOPLAKIA SHOWS NO ENRICHMENT OF MULTILOCUS SEQUENCE TYPING CLADES BUT ENRICHMENT OF ABC GENOTYPE C IN CANDIDA LEUKOPLAKIA
(2013)Oral leukoplakias are histopathologically-diagnosed as Candida leukoplakia or non-Candida leukoplakia by the presence or absence of hyphae in the superficial epithelium. Candida leukoplakia lesions have significantly ... -
EXTENSIVE GENETIC DIVERSITY IDENTIFIED AMONG SPORADIC METHICILLIN-RESISTANT Staphylococcus aureus ISOLATES RECOVERED IN IRISH HOSPITALS BETWEEN 2000-2012
(2014)Clonal replacement of predominant nosocomial methicillin-resistant Staphylococcus aureus (MRSA) strains has occurred several times in Ireland during the last four decades. However, little is known about sporadically-occurring ... -
MOLECULAR EPIDEMIOLOGY. PHYLOGENY AND EVOLUTION OF Candida albicans
(2014)A small number of Candida species form part of the normal microbial flora of mucosal surfaces in humans and may give rise to opportunistic infections when host defences are impaired. Candida albicans is by far the most ... -
PANTON-VALENTINE LEUKOCIDIN-POSITIVE STAPHYLOCOCCUS AUREUS IN IRELAND 2002-2011: TWENTY-ONE CLONES, FREQUENT IMPORTATION OF CLONES, TEMPORAL SHIFTS OF PREDOMINANT METHICILLIN-RESISTANT S. AUREUS AND INCREASING MULTIRESISTANCE
(2014)There has been a worldwide increase in community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA) infections. CA-MRSA isolates commonly produce the Panton-Valentine leukocidin toxin encoded by the pvl ... -
COMPARATIVE ADHERENCE OF CANDIDA ALBICANS AND CANDIDA DUBLINIENSIS TO HUMAN BUCCAL EPITHELIAL CELLS AND EXTRACELLULAR MATRIX PROTEINS
(2014)Candida albicans and Candida dubliniensis are very closely related pathogenic yeast species. Despite their close relationship, the former is a far more successful coloniser and pathogen of humans. The purpose of the current ... -
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.
(2008)Abstract: Lung cancer is the most common cause of cancer death worldwide, with over one million cases annually(1). To identify genetic factors that modify disease risk, we conducted a genome- wide association study by ... -
Using the International Classification of Functioning, Disability and Health (ICF) to Describe Children Referred to Special Care or Paediatric Dental Services.
(2013)Children in dentistry are traditionally described in terms of medical diagnosis and prevalence of oral disease. This approach gives little information regarding a child's capacity to maintain oral health or regarding the ... -
ENRICHMENT OF MULTILOCUS SEQUENCE TYPING CLADE 1 WITH ORAL CANDIDA ALBICANS ISOLATES IN PATIENTS WITH UNTREATED PERIODONTITIS
(2012)This study investigated the prevalence and cell density of Candida species in periodontal pockets, healthy subgingival sites and in oral rinses of patients with untreated periodontitis. Twenty-one periodontitis patients ... -
Detection of staphylococcal cassette chromosome mec type XI carrying highly divergent mecA, mecI, mecR1, blaZ, and ccr genes in human clinical isolates of clonal complex 130 methicillin-resistant Staphylococcus aureus.
(American Society for Microbiology, 2011)Methicillin resistance in staphylococci is mediated by penicillin binding protein 2a (PBP2a) encoded by mecA on mobile staphylococcal cassette chromosome mec (SCCmec) elements. In this study two clonal complex (CC) 130 ... -
Distribution of SCCmec-associated phenol-soluble modulin in staphylococci
(2012)The recently described phenol-soluble modulin PSM-mec was detected in S. aureus, S. epidermidis, S. fleuretti, S. hominis, S. pseudintermedius, S. saprophyticus, S. simulans and S. vitulinus from different hosts (humans, ... -
Cuspal deflection and microleakage in premolar teeth restored with bulk-fill flowable resin-based composite base materials
(Elsevier, 2012)Objectives: To assess the cuspal deflection and cervical microleakage of standardised Class II cavities incrementally filled with a dimethacrylate RBC or bulk-fill flowable RBC bases. Methods: Twenty-four sound upper ... -
The crushing truth about glass ionomer restoratives: exposing the standard of the standard
(Elsevier, 2012)Objectives: The compressive fracture strength (CFS) test is the only strength test for glass ionomers (GIs) in ISO 9917-1: 2003. The CFS test was the subject of much controversy in 1990 and has been challenged over its ... -
Improving the standard of the standard for glass ionomers: an alternative to the compressive fracture strength test for consideration?
(2012)Objectives: Three strength tests (compressive, three point flexure and biaxial) were performed on three glass ionomer (GI) restoratives to assess the most appropriate methodology in terms of validity and reliability. The ...
