Browsing Biochemistry by Sponsor "Biotechnology and Biological Sciences Research Council"
Now showing items 1-2 of 2
-
A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
(PLoS, 2007)The Toll-like receptor 4 (TLR4) is a class I transmembrane receptor expressed on the surface of immune system cells. TLR4 is activated by exposure to lipopolysaccharides derived from the outer membrane of Gram negative ... -
TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control ras-dependent amplification of NF-?B
(The American Society for Biochemistry and Molecular Biology, 2010)Host defense against infection is induced by Toll-like and interleukin (IL)-1 receptors, and controlled by the transcription factor NF-?B. Our earlier studies have shown that IL-1 activation impacts cytoskeletal structure ...